Evidence map›Paper›PMID 38342902›Full record

ArticleHuman genomics2024

Altered expression of serum lncRNA CASC2 and miRNA-21-5p in COVID-19 patients.

Shymaa E Ayoub, Olfat G Shaker, Mohamed Masoud, Essam A Hassan, Eman M Ezzat, Mona I Ahmed, Randa I Ahmed, Amal A Ibrahim Amin, Fadwa Abd El Reheem, Abeer A Khalefa and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. SARS-CoV-2 reshapes mNAR molecular medicine · 2025
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shymaa E AyoubDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, 63514, Egypt. ssa05@fayoum.edu.eg.ORCID 0000-0003-1688-3891
Olfat G ShakerDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed MasoudDepartment of Public Health and Community Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Essam A HassanDepartment of Tropical Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Eman M EzzatDepartment of Internal Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Mona I AhmedDepartment of Chest Disease and Tuberculosis, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Randa I AhmedDepartment of Chest Disease and Tuberculosis, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Amal A Ibrahim AminDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Fadwa Abd El ReheemDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Abeer A KhalefaDepartment of Physiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Rania H MahmoudDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, 63514, Egypt.
Fayoum University · EGCairo University · EGZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has a high incidence of spread. On January 30, 2020, the World Health Organization proclaimed a public health emergency of worldwide concern. More than 6.9 million deaths and more than 768 million confirmed cases had been reported worldwide as of June 18, 2023. This study included 51 patients and 50 age- and sex-matched healthy subjects. The present study aimed to identify the expression levels of lncRNA CASC2 and miRNA-21-5p (also known as miRNA-21) in COVID-19 patients and their relation to the clinicopathological characteristics of the disease. The expression levels of noncoding RNAs were measured by RT-PCR technique. Results detected that CASC2 was significantly downregulated while miRNA-21-5p was significantly upregulated in COVID-19 patients compared to healthy subjects. A significant negative correlation was found between CASC2 and miRNA-21-5p. ROC curve analysis used to distinguish COVID-19 patients from controls. MiRNA-21-p serum expression level had a significant positive association with temperature and PO2 (p = 0.04 for each). These findings indicate that CASC2 and miRNA-21-p might be used as potential diagnostic and therapeutic biomarkers in COVID-19.

Indexed as

COVID-19MicroRNAsRNA, Long NoncodingHumansSARS-CoV-2Tumor Suppressor ProteinsMicroRNAsMIRN21 microRNA, humanRNA, Long NoncodingTumor Suppressor ProteinsCOVID-19lncRNA CASC2miRNA-21-p

Identifiers

PMID38342902
PMCPMC10860220
OpenAlexW4391750474

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.