Evidence map›Paper›PMID 38345630›Full record

Trial reportJournal of neurology2024

Assessing the synergistic effectiveness of intermittent theta burst stimulation and the vestibular ocular reflex rehabilitation protocol in the treatment of Mal de Debarquement Syndrome: a randomised controlled trial.

Cherylea J Browne, S R Sheeba, T Astill, A Baily, C Deblieck, V Mucci, R Cavaleri

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Cherylea J BrowneSchool of Science, Western Sydney University, Sydney, NSW, Australia. c.browne@westernsydney.edu.au.ORCID http://orcid.org/0000-0001-6758-685X
S R SheebaSchool of Science, Western Sydney University, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-5980-974X
T AstillBrain Stimulation and Rehabilitation (BrainStAR) Laboratory, Western Sydney University, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-7009-2591
A BailySchool of Health Sciences, Western Sydney University, Sydney, NSW, Australia.ORCID http://orcid.org/0009-0001-6589-8806
C DeblieckLaboratory of Equilibrium Investigations and Aerospace (LEIA), University of Antwerp, Antwerp, Belgium.ORCID http://orcid.org/0000-0003-4498-6716
V MucciSchool of Science, Western Sydney University, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-7234-5292
R CavaleriBrain Stimulation and Rehabilitation (BrainStAR) Laboratory, Western Sydney University, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-9499-1703
Western Sydney University · AUTranslational Research Institute · AUUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMal de Debarquement Syndrome (MdDS) is a rare central vestibular disorder characterised by a constant sensation of motion (rocking, swaying, bobbing), which typically arises after motion experiences (e.g. sea, air, and road travel), though can be triggered by non-motion events. The current standard of care is non-specific medications and interventions that only result in mild-to-moderate improvements. The vestibular ocular reflex (VOR) rehabilitation protocol, a specialised form of rehabilitation, has shown promising results in reducing symptoms amongst people with MdDS. Accumulating evidence suggests that it may be possible to augment the effects of VOR rehabilitation via non-invasive brain stimulation protocols, such as theta burst stimulation (TBS).

methodsThe aim of this randomised controlled trial was to evaluate the effectiveness of intermittent TBS (iTBS) over the dorsolateral prefrontal cortex in enhancing the effectiveness of a subsequently delivered VOR rehabilitation protocol in people with MdDS. Participants were allocated randomly to receive either Sham (n = 10) or Active (n = 10) iTBS, followed by the VOR rehabilitation protocol. Subjective outcome measures (symptom ratings and mental health scores) were collected 1 week pre-treatment and for 16 weeks post-treatment. Posturography (objective outcome) was recorded each day of the treatment week.

resultsSignificant improvements in subjective and objective outcomes were reported across both treatment groups over time, but no between-group differences were observed. DISCUSSION: These findings support the effectiveness of the VOR rehabilitation protocol in reducing MdDS symptoms. Further research into iTBS is required to elucidate whether the treatment has a role in the management of MdDS. TRN: ACTRN12619001519145 (Date registered: 04 November 2019).

Indexed as

Reflex, Vestibulo-OcularTranscranial Magnetic StimulationAdultAgedCombined Modality TherapyFemaleHumansMaleMiddle AgedOutcome Assessment, Health CarePrefrontal CortexTheta RhythmTravel-Related IllnessMal de DebarquementMal de Debarquement SyndromeMdDSNeuro-otologyTheta burst stimulationVestibularVestibular rehabilitation

Identifiers

PMID38345630
PMCPMC11055743
OpenAlexW4391754872

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.