Evidence map›Paper›PMID 38347283›Full record

ReviewPediatric nephrology (Berlin, Germany)2024

Hemodiafiltration for children with stage 5 chronic kidney disease: technical aspects and outcomes.

Charlotte Ahlmann, Lynsey Stronach, Kathryn Waters, Kate Walker, Jun Oh, Claus Peter Schmitt, Bruno Ranchin, Rukshana Shroff

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Haemodiafiltration versus high-flux haemodialysis-a Consensus Statement from the EuDial Working Group of the ERA.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Charlotte AhlmannUniversity College London Great Ormond Street Hospital and Institute of Child Health, London, WC1N 3JH, UK.
Lynsey StronachUniversity College London Great Ormond Street Hospital and Institute of Child Health, London, WC1N 3JH, UK.
Kathryn WatersUniversity College London Great Ormond Street Hospital and Institute of Child Health, London, WC1N 3JH, UK.
Kate WalkerUniversity College London Great Ormond Street Hospital and Institute of Child Health, London, WC1N 3JH, UK.
Jun OhUniversity Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Claus Peter SchmittCentre for Pediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany.
Bruno RanchinHôpital Femme Mère Enfant, Hospices Civils de Lyon, Université de Lyon, Lyon, France.
Rukshana ShroffUniversity College London Great Ormond Street Hospital and Institute of Child Health, London, WC1N 3JH, UK. Rukshana.Shroff@gosh.nhs.uk.ORCID http://orcid.org/0000-0001-8501-1072
Great Ormond Street Hospital · GBUniversität Hamburg · DEHeidelberg University · DEUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite significant medical and technical improvements in the field of dialysis, the morbidity and mortality among patients with chronic kidney disease (CKD) stage 5 on dialysis remains extremely high. Hemodiafiltration (HDF), a dialysis method that combines the two main principles of hemodialysis (HD) and hemofiltration-diffusion and convection-has had a positive impact on survival when delivered with a high convective dose. Improved outcomes with HDF have been attributed to the following factors: HDF removes middle molecular weight uremic toxins including inflammatory cytokines, increases hemodynamic stability, and reduces inflammation and oxidative stress compared to conventional HD. Two randomized trials in adults have shown improved survival with HDF compared to high-flux HD. A large prospective cohort study in children has shown that HDF attenuated the progression of cardiovascular disease, improved bone turnover and growth, reduced inflammation, and improved blood pressure control compared to conventional HD. Importantly, children on HDF reported fewer headaches, dizziness, and cramps; had increased physical activity; and improved school attendance compared to those on HD. In this educational review, we discuss the technical aspects of HDF and results from pediatric studies, comparing outcomes on HDF vs. conventional HD. Convective volume, the cornerstone of treatment with HDF and a key determinant of outcomes in adult randomized trials, is discussed in detail, including the practical aspects of achieving an optimal convective volume.

Indexed as

HemodiafiltrationChildHumansKidney Failure, ChronicRenal Insufficiency, ChronicTreatment OutcomeBlood pressureCardiovascular diseaseChildrenGrowthHemodiafiltration (HDF)Hemodialysis (HD)

Identifiers

PMID38347283
PMCPMC11272808
OpenAlexW4391784604

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.