Evidence map›Paper›PMID 38347456›Full record

ArticleBMC pregnancy and childbirth2024

A prenatal case misunderstood as specimen confusion: 46,XY/46,XY chimerism.

Lin Chen, Li Wang, Yang Zeng, Daishu Yin, Feng Tang, Dan Xie, Hongmei Zhu, Lingping Li, Jing Wang

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lin ChenDepartment of Medical Genetics / Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Block 3 No. 20, Ren Min Nan Road, Wuhou District, Chengdu, 610041, China.
Li WangDepartment of Medical Genetics / Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Block 3 No. 20, Ren Min Nan Road, Wuhou District, Chengdu, 610041, China.
Yang ZengDepartment of Medical Genetics / Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Block 3 No. 20, Ren Min Nan Road, Wuhou District, Chengdu, 610041, China.
Daishu YinDepartment of Medical Genetics / Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Block 3 No. 20, Ren Min Nan Road, Wuhou District, Chengdu, 610041, China.
Feng TangDepartment of Medical Genetics / Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Block 3 No. 20, Ren Min Nan Road, Wuhou District, Chengdu, 610041, China.
Dan XieDepartment of Medical Genetics / Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Block 3 No. 20, Ren Min Nan Road, Wuhou District, Chengdu, 610041, China.
Hongmei ZhuDepartment of Medical Genetics / Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Block 3 No. 20, Ren Min Nan Road, Wuhou District, Chengdu, 610041, China.
Lingping LiDepartment of Medical Genetics / Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Block 3 No. 20, Ren Min Nan Road, Wuhou District, Chengdu, 610041, China.
Jing WangDepartment of Medical Genetics / Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Block 3 No. 20, Ren Min Nan Road, Wuhou District, Chengdu, 610041, China. hhwj_123@163.com.
West China Second University Hospital of Sichuan University · CNSichuan University · CN

Funding

National Key Research and Development Program of China No.2021YFC1005300
6 · The paper itself

Abstract

Chimerism results from the fusion of two zygotes in a single embryo, whereas mosaicism results from mitotic errors in a single zygote. True human chimerism is rare, with fewer than 100 cases reported in the literature. Here, we report a case in which the fetus was identified as having tetragametic chimerism based on short tandem repeat - polymerase chain reaction analysis of the family observed during amniocentesis for advanced maternal age. The chimerism occurred via the fertilization of two ova by two spermatozoa, followed by the fusion of early embryos. The genotypes of the two amniotic fluid samples obtained successively by one puncture were completely different, and the sex chromosomes were XY. Karyotyping and copy number variation sequencing showed no abnormalities. The fetus was delivered at term and the phenotype of the newborn was normal.

Indexed as

ChimerismDNA Copy Number VariationsAmniocentesisFemaleHumansInfant, NewbornKaryotypingMalePhenotypePregnancyChimerismPrenatal diagnosisShort tandem repeat

Identifiers

PMID38347456
PMCPMC10860253
OpenAlexW4391746940

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.