Evidence map›Paper›PMID 38348846›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2024

Development of certain benzylidene coumarin derivatives as anti-prostate cancer agents targeting EGFR and PI3Kβ kinases.

Mohamed Elagawany, Lina M A Abdel Ghany, Tarek S Ibrahim, Abdulrhman S Alharbi, Mohamed S Abdel-Aziz, Eman M El-Labbad, Noha Ryad

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Mohamed ElagawanyDepartment of Pharmaceutical Chemistry, Damanhour University, Damanhour, Buhaira, Egypt.
Lina M A Abdel GhanyPharmaceutical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Giza, Egypt.ORCID 0000-0003-3884-8755
Tarek S IbrahimDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID 0000-0002-3049-4617
Abdulrhman S AlharbiDepartment of Chemistry, College of Science and Arts, Shaqra University, Sajir, Shaqra, Saudi Arabia.
Mohamed S Abdel-AzizMicrobial Chemistry Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt.
Eman M El-LabbadDepartment of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates.
Noha RyadPharmaceutical Organic Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Giza, Egypt.ORCID 0000-0001-8813-5185
Misr University for Science and Technology · EGAin Shams University · EGDamanhour University · EGKing Abdulaziz University · SANational Research Centre · EGShaqra University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel coumarin derivatives were synthesised and tested for their cytotoxicity against human cancer cells (PC-3 and MDA-MB-231). Compounds

Indexed as

Antineoplastic AgentsNeoplasmsApoptosisCell Line, TumorCell ProliferationCoumarinsDrug Screening Assays, AntitumorErbB ReceptorsHumansMolecular Docking SimulationMolecular StructurePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktStructure-Activity RelationshipAntineoplastic AgentsCoumarinsEGFR protein, humanErbB ReceptorsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktapoptosisCoumarinscytotoxicitydockingPC-3

Identifiers

PMID38348846
PMCPMC10866054
OpenAlexW4391779907

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.