Evidence map›Paper›PMID 38349516›Full record

ArticleMolecular neurobiology2024

Neuroprotective Effect of a Multistrain Probiotic Mixture in SOD1

Zikai Xin, Cheng Xin, Jia Huo, Qi Liu, Hui Dong, Rui Li, Yaling Liu

Open access · hybridAbstract read
In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Integrative genomics and functional immunology reveal Clostridia species as modulators of neuroinflammation in amyotrophic lateral sclerosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  8. Article
  9. Article
  10. Microorganisms · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Gut microbiota immune cross-talk in amyotrophic lateral sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  16. Psychobiotic Properties ofInternational journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zikai XinDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Cheng XinDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Jia HuoDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Qi LiuDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Hui DongDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Rui LiDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. ruilidr@126.com.
Yaling LiuDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. lyldoctor@163.com.ORCID http://orcid.org/0000-0002-6221-6021
Hebei Medical University · CN

Funding

the Key Project of Technical Health Research and Achievement Transformation of Hebei Provincial Department of Health zh2018004the Natural Science Foundation of Hebei Province H2021206310
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the selective loss of motor neurons. A bidirectional communication system known as the "microbiota-gut-brain" axis has a regulatory function in neurodegenerative disorders. The impact of probiotics on ALS through the "microbiota-gut-brain" axis remains uncertain. A longitudinal investigation was conducted to examine the alterations in the structure of the ileum and colon in mutant superoxide dismutase 1 (SOD1

Indexed as

Amyotrophic Lateral SclerosisGastrointestinal MicrobiomeMice, TransgenicNeuroprotective AgentsProbioticsSuperoxide Dismutase-1AnimalsAutophagyBrainBrain-Gut AxisMaleMiceMice, Inbred C57BLProtein AggregatesSpinal CordNeuroprotective AgentsProtein AggregatesSuperoxide Dismutase-1Amyotrophic lateral sclerosisAutophagyEnteric nervous systemInflammationMicrobiota-gut-brain axisProtein aggregation

Identifiers

PMID38349516
PMCPMC11584480
OpenAlexW4391774448

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.