Evidence map›Paper›PMID 38352337›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Genome-wide association analysis of composite sleep health scores in 413,904 individuals.

Matthew O Goodman, Tariq Faquih, Valentina Paz, Pavithra Nagarajan, Jacqueline M Lane, Brian Spitzer, Matthew Maher, Joon Chung, Brian E Cade, Shaun M Purcell and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Matthew O GoodmanDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Tariq FaquihDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Valentina PazInstituto de Psicología Clínica, Facultad de Psicología, Universidad de la República, Montevideo, Uruguay.
Pavithra NagarajanDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Jacqueline M LaneDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Brian SpitzerDivision of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Matthew MaherCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Joon ChungDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Brian E CadeDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-1424-0673
Shaun M PurcellDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-7402-5812
Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Andrew J K PhillipsSchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.
Simon D KyleSir Jules Thorn Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Kai SpiegelhalderDepartment of Psychiatry and Psychotherapy, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Michael N WeedonGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Deborah A LawlorMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Carmen R IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Tamar SoferDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Hassan S DashtiBroad Institute, Cambridge, MA, USA.
Martin K RutterDivision of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Richa SaxenaBroad Institute, Cambridge, MA, USA.
Heming WangDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-1486-7495

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Phenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2M
Genetics of chronotype and impact on metabolic diseaseR01DK107859 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Richa Saxena · 2016 to 2026
$4.0M
Genetic Epidemiology of Sleep Apnea and Comorbidities in BiobanksR01HL153805 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CADE, BRIAN EDMAND · 2021 to 2025
$3.7M
Dissecting Causal Role of Insomnia in Cardiovascular DiseaseR01HL146751 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MELKANI, GIRISH C., SAXENA, RICHA · 2020 to 2023
$3.6M
Thalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6M
Leveraging human genetics to overcome complex diagnostic challenges, evaluation of pan-ancestry polygenic scores to reduce misdiagnosis of narcolepsy and circadian rhythm sleep wake disorders.R01HG012810 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel J Gottlieb · 2023 to 2026
$2.6M
Dissecting heterogeneity of excessive daytime sleepiness and impact on cardiovascular diseasesR01HL153814 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, HEMING · 2021 to 2025
$2.0M
Genetics of human circadian rhythms: using sequencing, novel phenotyping methods, and functional assays to move towards a deeper understanding of circadian mechanismsR35GM146839 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LANE, JACQUELINE MARIE · 2022 to 2025
$1.8M
GENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7M
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NCATS NIH HHS UL1 TR001881NHGRI NIH HHS HHSN268201300003CNHGRI NIH HHS R01 HG012810NHLBI NIH HHS HHSN268201300003INHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL146751NHLBI NIH HHS R01 HL153805NHLBI NIH HHS R01 HL153814NHLBI NIH HHS R35 HL135818NIDDK NIH HHS P30 DK063491Wellcome Trust
6 · The paper itself

Abstract

Recent genome-wide association studies (GWASs) of several individual sleep traits have identified hundreds of genetic loci, suggesting diverse mechanisms. Moreover, sleep traits are moderately correlated, and together may provide a more complete picture of sleep health, while also illuminating distinct domains. Here we construct novel sleep health scores (SHSs) incorporating five core self-report measures: sleep duration, insomnia symptoms, chronotype, snoring, and daytime sleepiness, using additive (SHS-ADD) and five principal components-based (SHS-PCs) approaches. GWASs of these six SHSs identify 28 significant novel loci adjusting for multiple testing on six traits (p<8.3e-9), along with 341 previously reported loci (p<5e-08). The heritability of the first three SHS-PCs equals or exceeds that of SHS-ADD (SNP-h

Identifiers

PMID38352337
PMCPMC10863010

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.