Evidence map›Paper›PMID 38352616›Full record

ArticlebioRxiv : the preprint server for biology2024

Macrophage Polarizations in the Placenta and Lung are Associated with Bronchopulmonary Dysplasia.

Karen K Mestan, Abhineet Sharma, Sarah Lazar, Sonalisa Pandey, Mana M Parast, Louise C Laurent, Lawrence S Prince, Debashis Sahoo

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Karen K MestanDepartment of Pediatrics, University of California San Diego, La Jolla, CA.
Abhineet SharmaDepartment of Pediatrics, Divisions of Neonatology and Pediatric Pulmonology, University of Nebraska College of Medicine, Omaha, NE.
Sarah LazarDepartment of Pediatrics, University of California San Diego, La Jolla, CA.
Sonalisa PandeyDepartment of Pediatrics, University of California San Diego, La Jolla, CA.
Mana M ParastDepartment of Pathology, University of California San Diego, La Jolla, CA.
Louise C LaurentDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, CA.
Lawrence S PrinceDepartment of Pediatrics, Stanford University, Stanford, CA.
Debashis SahooDepartment of Pediatrics, University of California San Diego, La Jolla, CA.
University of California San Diego · USStanford University · USUniversity of Nebraska at Omaha · US

Funding

Macrophage Polarization in Response to Infections and InflammationR01AI155696 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA, SAHOO, DEBASHIS · 2020 to 2024
$4.9M
Reference Profiles of ExRNAs in Normal Human PregnancyU01HL126494 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAURENT, LOUISE CHANG · 2014 to 2018
$3.4M
The Role of Placental Maternal Vascular Underperfusion in Neonatal Pulmonary HypertensionR01HL139798 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESTAN, KAREN K · 2018 to 2022
$2.5M
Human Trophoblast Stem Cells: the In Vivo Niche and Relationship to Pluripotent Stem CellsR01HD089537 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PARAST, MANA M · 2017 to 2021
$2.4M
Summer Student Research on the Application of Boolean AnalysisR01GM138385 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAHOO, DEBASHIS · 2020 to 2023
$2.0M
Development and application of a scalable workflow for immunomagnetic separation of exRNA carrier subclasses and molecular analysis of their cargoUG3CA241687 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAURENT, LOUISE CHANG · 2019 to 2020
$1.1M
Precision therapeutics of inflammatory bowel disease guided by Boolean logicUG3TR003355 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA, GHOSH, PRADIPTA · 2020 to 2022
$937k
NCATS NIH HHS UG3 TR003355NCI NIH HHS UG3 CA241687NHLBI NIH HHS R01 HL139798NHLBI NIH HHS U01 HL126494NIAID NIH HHS R01 AI155696NICHD NIH HHS R01 HD089537NIGMS NIH HHS R01 GM138385
6 · The paper itself

Abstract

The intricate interplay between macrophage polarization and placenta vascular dysfunction has garnered increasing attention in the context of placental inflammatory diseases. This study delves into the complex relationship between macrophage polarization within the placenta and its potential impact on the development of vascular dysfunction and inflammatory conditions. The placenta, a crucial organ in fetal development, relies on a finely tuned balance of immune responses for proper functioning. Disruptions in this delicate equilibrium can lead to pathological conditions, including inflammatory diseases affecting the fetus and newborn infant. We explored the interconnectedness between placental macrophage polarization and its relevance to lung macrophages, particularly in the context of early life lung development. Bronchopulmonary dysplasia (BPD), the most common chronic lung disease of prematurity, has been associated with abnormal immune responses, and understanding the role of macrophages in this context is pivotal. The investigation aims to shed light on how alterations in placental macrophage polarization may contribute to lung macrophage behavior and, consequently, influence the development of BPD. By unraveling the intricate mechanisms linking macrophage polarization, placental dysfunction and BPD, this research seeks to provide insights that could pave the way for targeted therapeutic interventions. The findings may offer novel perspectives on preventing and managing placental and lung-related pathologies, ultimately contributing to improved maternal and neonatal health outcomes.

Identifiers

PMID38352616
PMCPMC10862768
OpenAlexW4391345050

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.