Evidence map›Paper›PMID 38355715›Full record

Trial reportTranslational psychiatry2024

Cognitive and immunological effects of yoga compared to memory training in older women at risk for alzheimer's disease.

Adrienne Grzenda, Prabha Siddarth, Michaela M Milillo, Yesenia Aguilar-Faustino, Dharma S Khalsa, Helen Lavretsky

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03503669 (Reducing Risk for Alzheimer's Disease in High-Risk Women Through Yogic Meditation Training), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03503669 nacompletednot on this map

Reducing Risk for Alzheimer's Disease in High-Risk Women Through Yogic Meditation Training

TypeinterventionalSponsorUniversity of California, Los AngelesRan2018 to 2021Enrolled100ConditionsMild Cognitive Impairment, Alzheimer's DiseaseArmsMemory Training, Kundalini yoga and meditation
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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  4. Cognition in menopausal women.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Adrienne GrzendaDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, and Semel Institute for Neuroscience and Behavior, UCLA, Los Angeles, CA, USA.ORCID 0000-0001-5952-6953
Prabha SiddarthDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, and Semel Institute for Neuroscience and Behavior, UCLA, Los Angeles, CA, USA.
Michaela M MililloDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, and Semel Institute for Neuroscience and Behavior, UCLA, Los Angeles, CA, USA.ORCID 0000-0003-1370-8297
Yesenia Aguilar-FaustinoDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, and Semel Institute for Neuroscience and Behavior, UCLA, Los Angeles, CA, USA.
Dharma S KhalsaAlzheimer's Research and Prevention Foundation, Tucson, AZ, USA.
Helen LavretskyDepartment of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, and Semel Institute for Neuroscience and Behavior, UCLA, Los Angeles, CA, USA. hlavretsky@mednet.ucla.edu.ORCID 0000-0001-9990-5085
Alzheimer's Association · USNeurobehavioral Systems · USOlive View-UCLA Medical Center · US

Funding

Mentoring and Research in Translational Science of Integrative MedicineK24AT009198 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Helen Lavretsky · 2016 to 2026
$1.4M
NCCIH NIH HHS K24 AT009198
6 · The paper itself

Abstract

Subjective cognitive decline (SCD) and mild cognitive impairment (MCI) accompanied by cerebrovascular risk factors (CVRFs) are known to increase the risk of developing dementia. Mind-body practices such as yoga and meditation, have been recognized as safe techniques with beneficial effects on cognitive functions in older adults at risk for cognitive decline. We conducted a randomized, controlled trial to assess the efficacy of Kundalini yoga training (KY) compared to memory enhancement training (MET) on mood and cognitive functioning in a group of older women with CVRFs and SCD (clinicaltrials.gov = NCT03503669). The KY intervention consisted of weekly, 60-min in-person classes with a certified instructor for 12 weeks, with a 12-min guided recording for daily homework practice at home. MET involved 12 weekly in-person group classes with 12-min daily homework exercises. Objective and subjective memory performance were the primary outcomes. Peripheral whole blood samples were collected at baseline, 12-weeks, and 24-weeks follow-up for RNA sequencing and cytokine/chemokine assays. A total of 79 patients (KY = 40; MET = 39) were randomized, and 63 completed the 24-week follow-up (KY = 65% completion rate; MET = 95%; χ2(1) = 10.9, p < 0.001). At 24-weeks follow-up, KY yielded a significant, large effect size improvement in subjective cognitive impairment measures compared to MET. KYOn a transcriptional level, at 12- and 24-week follow-up, KY uniquely altered aging-associated signatures, including interferon gamma and other psycho-neuro-immune pathways. Levels of chemokine eotaxin-1, an aging marker, increased over time in MET but not KY participants. These results suggest clinical and biological benefits to KY for SCD, linking changes in cognition to the anti-inflammatory effects of yoga.

Indexed as

Alzheimer DiseaseCognitive DysfunctionMeditationYogaAgedChemokinesCognitionCognitive TrainingFemaleHumansChemokines

Identifiers

PMID38355715
PMCPMC10867110
OpenAlexW4391810608

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.