ArticleNature2024
Nuclear morphology is shaped by loop-extrusion programs.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 30 citations in OpenAlex.
- Nuclear mechanobiology rules immune cells' functions: from differentiation to cell trafficking and pathogen killing.Nucleus (Austin, Tex.) · 2026Review
- Base-pair resolution conservation data improves cell type specific sequence-to-expression prediction.Bioinformatics (Oxford, England) · 2026Article
- A generalizable Hi-C foundation model for chromatin architecture, single-cell and multiomics analysis across species.Nature methods · 2026Article
- Getting nuclear size just right - emerging mechanisms regulating nuclear scaling and morphology.Journal of cell science · 2026Review
- Metadomain and metaloop genome interactions in mammalian T cells.Cell reports · 2026Article
- Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation.Nature genetics · 2026Article
- Shaping neutrophil morphology and function: the importance of a segmented nucleus.Nature reviews. Immunology · 2026Review
- Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination.bioRxiv : the preprint server for biology · 2026Article
- Nuclear Mechanics and Nuclear Mechanotransduction in Cancer Cell Migration and Invasion.Biomolecules · 2026Review
- Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells.Science immunology · 2026Article
- An integrated multi-omics and network analysis of neutrophil differentiation from initial- to late-stage.Genome biology · 2026Article
- Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation.Nature cell biology · 2026Article
- NIPBL-mediated 3D genome folding translates enhancer priming into gene activation and safeguards lineage fidelity during embryonic transitions.bioRxiv : the preprint server for biology · 2025Article
- Spatial Chromatin Organization Across the Cell Cycle: Insights from Auxin-Inducible Protein Depletion.Cells · 2025Review
- CTCF couples long-range loop extrusion and diffusion to mediate a diverse Igκ repertoire.Nature communications · 2025Article
- The neutrophil collective.Cell · 2025Review
- Somatic mutations in STAG2 are associated with separated megakaryocyte nuclear lobes in myelodysplastic syndromes.Blood advances · 2025Article
- In Silico discovery of novel androgen receptor inhibitors for prostate cancer therapy using virtual screening, molecular docking, and molecular dynamics simulations.Scientific reports · 2025Article
- Spatial organization of chromatin restricts activation of poised alternative promoters in LTRs.Nature genetics · 2025Article
- Advanced Microarrays as Heterogeneous Force-Remodeling Coordinator to Orchestrate Nuclear Configuration and Force-Sensing Mechanotransduction in Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Indumathi PattaDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Maryam ZandDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Lindsay LeeDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Shreya MishraDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Alexandra BortnickDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Hanbin LuDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Arpita PrustyDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-2247-4402
Sara McArdleMicroscopy and Histology Core Facility, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0003-3795-3772
Zbigniew MikulskiMicroscopy and Histology Core Facility, La Jolla Institute for Immunology, La Jolla, CA, USA.
Huan-You WangDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Christine S ChengDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Kathleen M FischDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA. kfish@health.ucsd.edu.ORCID 0000-0002-0117-7444
Ming HuDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. hum@ccf.org.ORCID 0000-0003-0987-2916
Cornelis MurreDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA, USA. cmurre@ucsd.edu.ORCID 0000-0003-2437-507X
University of California San Diego · USCleveland Clinic · USLa Jolla Institute for Immunology · USUC San Diego Health System · US
Funding
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3MThe role of TCR, ligand, and signal strength in human γδ T cell developmentP01AI102853 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI DAVID L. WIEST · 2014 to 2026
$26.3MSan Diego Center for 4D Nucleome ResearchU54DK107977 · NIDDK · LUDWIG INSTITUTE FOR CANCER RES LTD · PI MURRE, CORNELIS, REN, BING · 2015 to 2019
$9.4MSingle Cell Transcriptomics of the Cocaine Use Disorder in the Context of HIVU01DA056006 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christine Cheng, DAVID J MOORE · 2022 to 2026
$7.9MCenter for Integrated Multi-modal and Multi-scale Nucleome ResearchUM1HG011585 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DULAC, CATHERINE, LEIN, ED · 2020 to 2024
$6.7MSingle Cell Transcriptomics of the Opioid Use Disorder and HIV Syndemic in the Human BrainUM1DA051411 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHENG, CHRISTINE · 2020 to 2024
$5.1MSingle nuclei transcriptomics of Alzheimer's brain diseaseR61DA047032 · NIDA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, CHRISTINE, HENDERSON, ANDREW J · 2018 to 2020
$3.5MSynergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV InfectionR01DA051889 · NIDA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHENG, CHRISTINE, GUMMULURU, SURYARAM · 2020 to 2024
$3.5MModel-based methods for single cell chromatin interactomic dataR35HG011922 · NHGRI · CLEVELAND CLINIC LERNER COM-CWRU · PI HU, MING · 2021 to 2025
$2.4MEffect of opioid use disorder on HIV latent reservoirs and immune dysfunction assessed by single-cell transcriptomicsR33DA047032 · NIDA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, CHRISTINE, HENDERSON, ANDREW J · 2021 to 2022
$1.8MExploring the Pathophysiology of AD and ADRDs with 3D Asteroid ModelsR56AG074591 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHENG, CHRISTINE, WOLOZIN, BENJAMIN L · 2021 to 2021
$916kIllumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600kNCATS NIH HHS UL1 TR001442NHGRI NIH HHS R35 HG011922NHGRI NIH HHS UM1 HG011585NIAID NIH HHS P01 AI102853NIA NIH HHS R56 AG074591NIDA NIH HHS R01 DA051889NIDA NIH HHS R33 DA047032NIDA NIH HHS R61 DA047032NIDA NIH HHS U01 DA056006NIDA NIH HHS UM1 DA051411NIDDK NIH HHS U54 DK107977NIH HHS S10 OD026929NIH HHS S10 OD030417
Abstract
It is well established that neutrophils adopt malleable polymorphonuclear shapes to migrate through narrow interstitial tissue spaces
Indexed as
Cell MovementCell Nucleus ShapeNeutrophilsCell Cycle CheckpointsCell Cycle ProteinsCell DifferentiationCell LineageChromatinChromosomesEnhancer Elements, GeneticInflammationNucleic Acid ConformationCell Cycle ProteinsChromatin
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.