Trial reportGut microbes
Gut enterotype-dependent modulation of gut microbiota and their metabolism in response to xanthohumol supplementation in healthy adults.
Open access · goldAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of Soluble Corn Fiber Consumption on Executive Functions and Gut Microbiota in Middle to Older Age Adults: A Randomized Controlled Crossover Trial.The Journal of nutrition · 2026Trial
- Modulation of Microbiota-Derived Bile Acids Linked to Symptom Amelioration in Crohn's Disease: Insights From a Randomized Clinical Trial With Xanthohumol Supplementation.Molecular nutrition & food research · 2026Trial
- Safety and Tolerability of Xanthohumol in Adults With Crohn's Disease: Results of a Triple-Masked, Randomized, Placebo-Controlled Phase 2 Trial.Molecular nutrition & food research · 2026Trial
- Dietary Bioactive Compounds: Cellular Sensory Pathways, Microbial Partners, and Clinical Realities.Nutrients · 2026Review
- The Gut Microbiome and Diet Interact to Dictate Personalized Response to Broccoli Sprout Consumption.Food science & nutrition · 2026Article
- Plant-derived soft electrophiles upregulate pro-resolving oxylipins in a paraquat-inducedbioRxiv : the preprint server for biology · 2026Article
- Antibacterial efficacy and mechanisms of hawthorn leaf extract against poultry-derived Staphylococcus aureus and Escherichia coli: potential as natural food preservatives.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Proteomic antibacterial characterization of flavonoid xanthohumol and probiotic Clostridium butyricum on pathogenic Clostridioides difficile.Chinese medicine · 2026Article
- Review
- Diet, gut microbiome, and cognition in neurodegeneration: a review and methodological framework.Frontiers in aging neuroscience · 2026Review
- Clinical evidence for microbial-derived polyphenol metabolites in health and disease: a scoping review.Frontiers in nutrition · 2026Review
- Apple consumption is associated with obesity- and lipid-related parameters and gut microbiota profiles across enterotypes: 12-week single-blind trial in Japanese adults.Frontiers in nutrition · 2026Article
- The gut-bone axis: potential influence of anthocyanins and implications for postmenopausal osteoporosis.Food science and biotechnology · 2026Review
- Xanthohumol Alters Gut Microbiota Metabolism and Bile Acid Dynamics in Gastrointestinal Simulation Models of Eubiotic and Dysbiotic States.International journal of molecular sciences · 2025Article
- Effects of Athletic Nutritional Supplements on the Human Gut Microbiota: A Narrative Review.Nutrients · 2025Review
- Bacteroides- and Prevotella-enriched gut microbial clusters associate with metabolic risks.Gut pathogens · 2025Article
- (Poly)phenol-gut microbiota interactions and their impact on human health.Current opinion in clinical nutrition and metabolic care · 2025Review
- Effect of Antioxidants on the Gut Microbiome Profile and Brain Functions: A Review of Randomized Controlled Trial Studies.Foods (Basel, Switzerland) · 2025Review
- Distinct Gut Microbial Enterotypes and Functional Dynamics in Wild Striped Field Mice (Microorganisms · 2024Article
- Acid-assisted polysaccharides extracted fromFrontiers in nutrition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Paige E JamiesonCollege of Health, Oregon State University, Corvallis, OR, USA.ORCID 0009-0006-1492-8063
Eli B SmartLinus Pauling Institute, Oregon State University, Corvallis, OR, USA.
John A BouranisCollege of Health, Oregon State University, Corvallis, OR, USA.ORCID 0000-0002-5533-7570
Jaewoo ChoiLinus Pauling Institute, Oregon State University, Corvallis, OR, USA.ORCID 0000-0001-6376-3089
Robert E DanczakEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0003-1396-192X
Carmen P WongLinus Pauling Institute, Oregon State University, Corvallis, OR, USA.ORCID 0000-0001-8294-2584
Ines L ParaisoLinus Pauling Institute, Oregon State University, Corvallis, OR, USA.ORCID 0000-0001-8796-6702
Claudia S MaierLinus Pauling Institute, Oregon State University, Corvallis, OR, USA.ORCID 0000-0003-0743-8956
Emily HoCollege of Health, Oregon State University, Corvallis, OR, USA.ORCID 0000-0002-7687-2820
Thomas J SharptonDepartment of Statistics, Oregon State University, Corvallis, OR, USA.ORCID 0000-0002-5996-7764
Thomas O MetzEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0001-6049-3968
Ryan BradleyHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.ORCID 0000-0002-8073-3671
Jan F StevensLinus Pauling Institute, Oregon State University, Corvallis, OR, USA.ORCID 0000-0002-6348-9347
Oregon State University · USPacific Northwest National Laboratory · USNational University of Natural Medicine · US
Funding
Discovery and Biological Signatures of Microbiome-Derived Xanthohumol Metabolites and their Role in Ameliorating Inflammatory Bowel DiseaseR01AT010271 · NCCIH · OREGON STATE UNIVERSITY · PI BRADLEY, RYAN D, METZ, THOMAS O · 2018 to 2021
$1.8MMentorship in Clinical Complementary and Integrative Health ResearchK24AT011568 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRADLEY, RYAN D · 2021 to 2025
$762kUltra-Performance Liquid Chromatography Tandem Quadrupole Mass Spectrometry SystemS10OD026922 · OD · OREGON STATE UNIVERSITY · PI MAIER, CLAUDIA S · 2019 to 2019
$577kTriple Quadrupole/Linear Ion Trap LC-MS/MS for LPIS10RR027878 · NCRR · OREGON STATE UNIVERSITY · PI STEVENS, JAN FREDERIK · 2010 to 2010
$484kHYBRID TRIPLE QUADRUPOLE LINEAR ION TRAP MASS SPECTROMETER: PROSTATE CANCERS10RR022589 · NCRR · OREGON STATE UNIVERSITY · PI STEVENS, JAN FREDERIK · 2006 to 2006
$343kNCCIH NIH HHS K24 AT011568NCCIH NIH HHS R01 AT010271NCRR NIH HHS S10 RR022589NCRR NIH HHS S10 RR027878NIH HHS S10 OD026922
Abstract
Xanthohumol (XN), a polyphenol found in the hop plant (
Indexed as
Gastrointestinal MicrobiomePropiophenonesAdultFlavonoidsHumansPrebioticsRNA, Ribosomal, 16SFlavonoidsPrebioticsPropiophenonesRNA, Ribosomal, 16SxanthohumolenterotypesGut microbiotamicrobial metabolismphytochemicalpolyphenolprecision medicine
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.