Evidence map›Paper›PMID 38358663›Full record

ArticleDevelopmental psychology2024

Contributions of prenatal risk factors and neonatal epigenetics to cognitive outcome in children born very preterm.

Marie Camerota, Barry M Lester, Elisabeth C McGowan, Brian S Carter, Jennifer Check, Lynne M Dansereau, Sheri A DellaGrotta, Jennifer B Helderman, Julie A Hofheimer, Cynthia M Loncar and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Developmental psychology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 1 country.

Marie CamerotaDepartment of Psychiatry and Human Behavior, Alpert Medical School, Brown University.ORCID 0000-0001-8293-6467
Barry M LesterDepartment of Psychiatry and Human Behavior, Alpert Medical School, Brown University.
Elisabeth C McGowanBrown Center for the Study of Children at Risk, Alpert Medical School, Brown University.
Brian S CarterDepartment of Pediatrics-Neonatology, Children's Mercy Hospital.
Jennifer CheckDepartment of Pediatrics, Wake Forest School of Medicine.
Lynne M DansereauDepartment of Pediatrics, Alpert Medical School, Brown University.
Sheri A DellaGrottaDepartment of Pediatrics, Alpert Medical School, Brown University.
Jennifer B HeldermanDepartment of Pediatrics, Wake Forest School of Medicine.
Julie A HofheimerDepartment of Pediatrics, University of North Carolina at Chapel Hill School of Medicine.
Cynthia M LoncarDepartment of Psychiatry and Human Behavior, Alpert Medical School, Brown University.
Charles R NealDepartment of Pediatrics, John A. Burns School of Medicine, University of Hawaii.
T Michael O'SheaDepartment of Pediatrics, University of North Carolina at Chapel Hill School of Medicine.
Steven L PastyrnakDepartment of Pediatrics, Spectrum Health-Helen DeVos Hospital.
Lynne M SmithDepartment of Pediatrics, Harbor-UCLA Medical Center.
Sarina AbrishamcarDepartment of Epidemiology, Emory University Rollins School of Public Health.
Anke HülsDepartment of Epidemiology, Emory University Rollins School of Public Health.
Carmen J MarsitDepartment of Epidemiology, Emory University Rollins School of Public Health.
Todd M EversonDepartment of Epidemiology, Emory University Rollins School of Public Health.
Brown University · USEmory University · USUniversity of North Carolina at Chapel Hill · USWake Forest University · USChildren's Mercy Hospital · USHarbor–UCLA Medical Center · USHelen DeVos Children's Hospital · USUniversity of Hawaiʻi at Mānoa · US

Funding

ENVIRONMENTAL INFLUENCES ON NEURODEVELOPMENTAL OUTCOME IN INFANTS BORN VERY PRETERMUG3OD023347 · OD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M., MARSIT, CARMEN JOSEPH · 2016 to 2017
$5.2M
Epigenetic Predictors of Impairment in Very Preterm InfantsR01HD084515 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI EVERSON, TODD M, LESTER, BARRY M. · 2016 to 2023
$3.9M
Neonatal Neurobehavior and Outcomes in Very Preterm InfantsR01HD072267 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M., O'SHEA, MICHAEL · 2013 to 2017
$3.3M
Longitudinal Antecedents of Attention Problems in Very Preterm Children: Role of Epigenetics, Executive Function, and Caregiver Psychological DistressK01MH129510 · NIMH · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI Marie Camerota · 2022 to 2026
$947k
NICHD NIH HHS R01 HD072267NICHD NIH HHS R01 HD084515NIH HHS UG3 OD023347NIMH NIH HHS K01 MH129510
6 · The paper itself

Abstract

Children born less than 30 weeks gestational age (GA) are at high risk for neurodevelopmental delay compared to term peers. Prenatal risk factors and neonatal epigenetics could help identify preterm children at highest risk for poor cognitive outcomes. We aimed to understand the associations among cumulative prenatal risk, neonatal DNA methylation, and child cognitive ability at age 3 years, including whether DNA methylation mediates the association between prenatal risk and cognitive ability. We studied 379 neonates (54% male) born less than 30 weeks GA who had DNA methylation measured at neonatal intensive care unit discharge along with 3-year follow-up data. Cumulative prenatal risk was calculated from 24 risk factors obtained from maternal report and medical record and epigenome-wide neonatal DNA methylation was assayed from buccal swabs. At 3-year follow-up, child cognitive ability was assessed using the

Indexed as

DNA MethylationEpigenesis, GeneticInfant, Extremely PrematureChild DevelopmentChild, PreschoolCognitionFemaleFollow-Up StudiesHumansInfant, NewbornMalePregnancyPrenatal Exposure Delayed EffectsRisk Factors

Identifiers

PMID38358663
PMCPMC11618652
OpenAlexW4391844545

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.