Evidence map›Paper›PMID 38362022›Full record

ArticleFrontiers in neuroscience2024

Multiple steps of prion strain adaptation to a new host.

Olga Bocharova, Natallia Makarava, Narayan P Pandit, Kara Molesworth, Ilia V Baskakov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. TDP-43 Aggregation: The Healthy-Toxic Balance of the Prion-Like Domain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Olga Bocharova *Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, United States.
Natallia Makarava *Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, United States.
Narayan P PanditCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, United States.
Kara MolesworthCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, United States.
Ilia V BaskakovCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, United States.
University of Maryland, Baltimore · US

Funding

Self-Propagating Mechanism of Prion DiseasesR01NS045585 · NINDS · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI Ilia V Baskakov · 2003 to 2026
$9.6M
Role of reactive astrocytes in prion diseasesR01NS129502 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI Ilia V Baskakov · 2023 to 2026
$2.5M
NINDS NIH HHS R01 NS045585NINDS NIH HHS R01 NS129502
6 · The paper itself

Abstract

The transmission of prions across species is a critical aspect of their dissemination among mammalian hosts, including humans. This process often necessitates strain adaptation. In this study, we sought to investigate the mechanisms underlying prion adaptation while mitigating biases associated with the history of cross-species transmission of natural prion strains. To achieve this, we utilized the synthetic hamster prion strain S05. Propagation of S05 using mouse PrP

Indexed as

cross-species barrierneurodegenerative diseasesN-linked glycansprionprion adaptationprion diseasesprion strainssialylation

Identifiers

PMID38362022
PMCPMC10867973
OpenAlexW4391397908

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.