Evidence map›Paper›PMID 38362731›Full record

ReviewFuture oncology (London, England)2024

Measuring the composition of the tumor microenvironment with transcriptome analysis: past, present and future.

Han Zhang, Xinghua Lu, Binfeng Lu, Giuseppe Gullo, Lujia Chen

Open access · hybridAbstract readReview
In one paragraph

Review in Future oncology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Translational cancer research · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Han ZhangDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15206, USA.ORCID 0000-0003-3023-4767
Xinghua LuDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15206, USA.ORCID 0000-0002-8599-2269
Binfeng LuCenter for Discovery & Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.ORCID 0000-0002-7822-5950
Giuseppe GulloDepartment of Obstetrics & Gynecology, Villa Sofia Cervello Hospital, University of Palermo, 90146, Palermo, Italy.ORCID 0000-0003-4269-4269
Lujia ChenDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15206, USA.ORCID 0000-0003-4157-0440
University of Pittsburgh · USHackensack Meridian Health · USOspedale Vincenzo Cervello · IT

Funding

Developing deep learning models for precision oncologyR00LM013089 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, LUJIA · 2022 to 2024
$691k
NLM NIH HHS R00 LM013089US National Library of Medicine R00LM013089
6 · The paper itself

Abstract

Interactions between tumor cells and immune cells in the tumor microenvironment (TME) play a vital role the mechanisms of immune evasion, by which cancer cells escape immune elimination. Thus, the characterization and quantification of different components in the TME is a hot topic in molecular biology and drug discovery. Since the development of transcriptome sequencing in bulk tissue, single cells and spatial dimensions, there are increasing methods emerging to deconvolute and subtype the TME. This review discusses and compares such computational strategies and downstream subtyping analyses. Integrative analyses of the transcriptome with other data, such as epigenetics and T-cell receptor sequencing, are needed to obtain comprehensive knowledge of the dynamic TME.

Indexed as

Gene Expression ProfilingNeoplasmsTranscriptomeTumor MicroenvironmentBiomarkers, TumorComputational BiologyGene Expression Regulation, NeoplasticHumansBiomarkers, Tumorbulk-RNAseqcell-cell networkdeconvolutionimmune phenotypeimmunotherapyscRNAseqspatial transcriptomeTME subtypetumor microenvironment

Identifiers

PMID38362731
PMCPMC11318690
OpenAlexW4391909346

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.