ArticleThe Journal of clinical endocrinology and metabolism2024
Magnesium Depletion Score and Metabolic Syndrome in US Adults: Analysis of NHANES 2003 to 2018.
Article in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- Enhanced Metabolic Risks in Patients with Obesity and Nutritional Deficiencies in the U.S.: A TriNetX Study.Nutrients · 2026Article
- A metabolic-inflammatory phenotype of pelvic floor dysfunction: A machine learning-based cross-sectional study in a nationally representative US population.The Journal of international medical research · 2026Article
- Hypomagnesemia: A Clinical and Nutritional Update.Current nutrition reports · 2026Review
- Association of serum magnesium, total and ionized calcium levels with ICU mortality: A 208-hospital retrospective analysis.Journal of medical biochemistry · 2026Article
- Magnesium Level and Related Factors in Type 2 Diabetes Mellitus: A Cross-Sectional StudyEndocrine, metabolic & immune disorders drug targets · 2026Article
- Association of magnesium depletion score, triglyceride-glucose index, and C-reactive protein-albumin-lymphocyte index with diabetic sarcopenia: a cross-sectional study based on NHANES 2014-2018 data.American journal of translational research · 2026Article
- The Relationship Between Magnesium Depletion Score and Kidney Stone Risk in Gout Patients: a Mediation Analysis.Biological trace element research · 2025Article
- Magnesium Depletion Score as an Indicator of Health Risk and Nutritional Status-A Scoping Review.Nutrients · 2025Article
- Association between magnesium depletion score and overactive bladder among U.S. Adults using data from NHANES 2005-2018.Scientific reports · 2025Article
- Hypomagnesemia: exploring its multifaceted health impacts and associations with blood pressure regulation and metabolic syndrome.Diabetology & metabolic syndrome · 2025Review
- The association between magnesium depletion score (MDS) and overactive bladder (OAB) among the U.S. population.Journal of health, population, and nutrition · 2025Article
- Potential association between magnesium depletion score and hyperuricemia in American adults, a cross-sectional study based on NHANES 2003-2018.Preventive medicine reports · 2025Article
- Article
- Higher magnesium depletion score increases the risk of all‑cause and cardiovascular mortality in US adults with diabetes.PloS one · 2025Article
- Association of magnesium depletion score with serum anti-aging protein Klotho in the middle-aged and older populations.Frontiers in nutrition · 2025Article
- Association between Magnesium Depletion Score and Advanced Cardiovascular-Kidney-Metabolic Syndrome Stages in US Adults.International journal of medical sciences · 2025Article
- Accelerated biological aging as a potential mediator mediates the relationship between metabolic syndrome and the risk of psoriasis: a prospective analysis from the UK biobank.Frontiers in immunology · 2025Article
- Magnesium depletion score is a risk factor for all-cause, cancer and cardiovascular disease mortality in cancer survivors: evidence from two prospective cohort studies.Frontiers in nutrition · 2025Article
- Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018.Frontiers in endocrinology · 2025Article
- Increased magnesium intake does not mitigate MAFLD risk associated with magnesium deficiency.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
contextThe association between magnesium status and metabolic syndrome (MetS) remains unclear.
objectiveThis study aimed to examine the relationship between kidney reabsorption-related magnesium depletion score (MDS) and MetS among US adults.
methodsWe analyzed data from 15 565 adults participating in the National Health and Nutrition Examination Survey (NHANES) 2003 to 2018. MetS was defined according to the National Cholesterol Education Program's Adult Treatment Panel III report. The MDS is a scoring system developed to predict the status of magnesium deficiency that fully considers the pathophysiological factors influencing the kidneys' reabsorption capability. Weighted univariate and multivariable logistic regression were used to assess the association between MDS and MetS. Restricted cubic spline (RCS) analysis was conducted to characterize dose-response relationships. Stratified analyses by sociodemographic and lifestyle factors were also performed.
resultsIn both univariate and multivariable analyses, higher MDS was significantly associated with increased odds of MetS. Each unit increase in MDS was associated with approximately a 30% higher risk for MetS, even after adjusting for confounding factors (odds ratio 1.31; 95% CI, 1.17-1.45). RCS graphs depicted a linear dose-response relationship across the MDS range. This positive correlation remained consistent across various population subgroups and exhibited no significant interaction by age, sex, race, adiposity, smoking status, or alcohol consumption.
conclusionHigher urinary magnesium loss as quantified by MDS may be an independent linear risk factor for MetS in US adults, irrespective of sociodemographic and behavioral factors. Optimizing magnesium nutritional status could potentially confer benefits to patients with MetS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.