Evidence map›Paper›PMID 38368218›Full record

ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2024

Addressing long-term mortality risk in patients undergoing total pancreatectomy with islet autotransplant (TPIAT): causes of death and risk factors.

Gregory Hooks, Han Lu, Anne Eaton, Guru Trikudanathan, Elissa Downs, Martin L Freeman, Sarah J Schwarzenberg, Timothy L Pruett, Srinath Chinnakotla, Karthik Ramanathan and 2 more

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In one paragraph

Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gregory HooksDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Han LuDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Anne EatonDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Guru TrikudanathanDepartment of Internal Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Elissa DownsDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Martin L FreemanDepartment of Internal Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Sarah J SchwarzenbergDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Timothy L PruettDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
Srinath ChinnakotlaDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
Karthik RamanathanDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
Gregory J BeilmanDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
Melena D BellinDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA. Electronic address: bell0130@umn.edu.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Long-Term Islet Function and Impact after Total Pancreatectomy with Islet Autotransplant (LIFT)R01DK126728 · NIDDK · UNIVERSITY OF MINNESOTA · PI BELLIN, MELENA D. · 2021 to 2025
$3.2M
NCATS NIH HHS UL1 TR002494NIDDK NIH HHS R01 DK126728
6 · The paper itself

Abstract

backgroundTotal pancreatectomy with islet autotransplant (TPIAT) can improve quality of life for individuals with pancreatitis but creates health risks including diabetes, exocrine insufficiency, altered intestinal anatomy and function, and asplenia.

methodsWe studied survival and causes of death for 693 patients who underwent TPIAT between 2001 and 2020, using the National Death Index with medical records to ascertain survival after TPIAT, causes of mortality, and risk factors for death. We used Kaplan Meier curves to examine overall survival, and Cox regression and competing-risks methods to determine pre-TPIAT factors associated with all-cause and cause-specific post-TPIAT mortality.

resultsMean age at TPIAT was 33.6 years (SD = 15.1). Overall survival was 93.1% (95% CI 91.2, 95.1%) 5 years after surgery, 85.2% (95% CI 82.0, 88.6%) at 10 years, and 76.2% (95% CI 70.8, 82.3%) at 15 years. Fifty-three of 89 deaths were possibly related to TPIAT; causes included chronic gastrointestinal complications, malnutrition, diabetes, liver failure, and infection/sepsis. In multivariable models, younger age, longer disease duration, and more recent TPIAT were associated with lower mortality.

conclusionsFor patients undergoing TPIAT to treat painful pancreatitis, careful long-term management of comorbidities introduced by TPIAT may reduce risk for common causes of mortality.

Indexed as

Cause of DeathIslets of Langerhans TransplantationPancreatectomyAdolescentAdultFemaleHumansMaleMiddle AgedPancreatitisPancreatitis, ChronicRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTransplantation, Autologous

Identifiers

PMID38368218
PMCPMC11070297

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.