Evidence map›Paper›PMID 38368459›Full record

ArticleNature communications2024

Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X

Fengwei Li, Junjie Liu, Chao Liu, Ziyan Liu, Xiangda Peng, Yinyue Huang, Xiaoyu Chen, Xiangnan Sun, Sen Wang, Wei Chen and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
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  4. De novo discovery of a molecular glue-like macrocyclic peptide that induces MCL1 homodimerization.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Fengwei Li *Helmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China. lifengwei@sdu.edu.cn.ORCID 0000-0002-7143-4151
Junjie Liu *The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
Chao Liu *Helmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.
Ziyan LiuThe MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
Xiangda PengShanghai Zelixir Biotech Company Ltd., Shanghai, 200030, China.
Yinyue HuangHelmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.
Xiaoyu ChenHelmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.
Xiangnan SunHelmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.
Sen WangHelmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.
Wei ChenShanghai Immune Therapy Institute, Shanghai Jiao Tong University School of Medicine-Affiliated Renji Hospital, Shanghai, 200127, China.
Dan XiongXiamen Lifeint Technology Company Ltd., Xiamen, 361005, China.
Xiaotong DiaoHelmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.ORCID 0000-0001-8449-6688
Sheng WangShanghai Zelixir Biotech Company Ltd., Shanghai, 200030, China.
Jingjing ZhuangHelmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.
Chuanliu WuThe MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China. chlwu@xmu.edu.cn.ORCID 0000-0003-2946-7299
Dalei WuHelmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China. dlwu@sdu.edu.cn.ORCID 0000-0003-1817-7229
Shandong University · CNXiamen University · CNShanghai Jiao Tong University · CNViva Biotech (China) · CN

Funding

Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2021JQ30
6 · The paper itself

Abstract

Overexpressed pro-survival B-cell lymphoma-2 (BCL-2) family proteins BCL-2 and BCL-X

Indexed as

Antineoplastic AgentsPeptides, CyclicApoptosisbcl-X ProteinBridged Bicyclo Compounds, HeterocyclicCell Line, TumorProto-Oncogene Proteins c-bcl-2SulfonamidesAntineoplastic Agentsbcl-X ProteinBridged Bicyclo Compounds, HeterocyclicPeptides, CyclicProto-Oncogene Proteins c-bcl-2Sulfonamidesvenetoclax

Identifiers

PMID38368459
PMCPMC10874388
OpenAlexW4391896628

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.