Evidence map›Paper›PMID 38369335›Full record

ArticleMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine2025

Kidney R2* Mapping for Noninvasive Evaluation of Iron Overload in Paroxysmal Nocturnal Hemoglobinuria.

Koichi Ito, Kazuyuki Ohgi, Koichiro Kimura, Koichi Ishitaki, Akiyoshi Yamashita, Hiroyuki Yokote, Shunji Tsukuda, Ko Matsushita, Yuko Naraoka, Amon Fujioka and 1 more

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In one paragraph

Article in Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Koichi ItoDepartment of Radiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Kazuyuki OhgiDepartment of Radiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Koichiro KimuraDepartment of Radiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Koichi IshitakiDepartment of Radiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Akiyoshi YamashitaDepartment of Radiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Hiroyuki YokoteDepartment of Radiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Shunji TsukudaDepartment of Radiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Ko MatsushitaDepartment of Radiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Yuko NaraokaDepartment of Radiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Amon FujiokaDepartment of Radiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Tatsuki OnoDepartment of Radiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Japanese Red Cross Medical Center · JPTokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe kidney iron deposition can cause kidney damage and renal insufficiency in paroxysmal nocturnal hemoglobinuria (PNH) patients. Assessment of iron deposition in the kidney is essential for the early diagnosis of renal damage in PNH patients. The purpose of this study was to evaluate kidney R2* (T2* reciprocals) values in PNH patients using the iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ).

methodsTwo radiologists measured the R2* values of the renal cortex in 14 PNH patients and 13 healthy volunteers using IDEAL-IQ. Lactate dehydrogenase (LDH), a reliable marker of intravascular hemolysis, was also measured in all participants.

resultsThe kidney R2* values were significantly higher in PNH patients compared with those in healthy volunteers (P < 0.001). High inter-operator reproducibility of the measurements was also acquired using IDEAL-IQ. LDH levels were also significantly higher in PNH patients compared with those in healthy volunteers (P < 0.001). Kidney R2* values strongly correlated with LDH levels in PNH patients.

conclusionIDEAL-IQ has a possibility of becoming a useful method for the noninvasive evaluation of renal iron overload in PNH patients.

Indexed as

Hemoglobinuria, ParoxysmalIron OverloadKidneyMagnetic Resonance ImagingAdultAgedFemaleHumansImage Interpretation, Computer-AssistedL-Lactate DehydrogenaseMaleMiddle AgedReproducibility of ResultsYoung AdultL-Lactate Dehydrogenaseiron depositionkidneymagnetic resonance imagingparoxysmal nocturnal hemoglobinuriaR2* mapping

Identifiers

PMID38369335
PMCPMC11996248
OpenAlexW4391854054

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.