Evidence map›Paper›PMID 38370338›Full record

ArticleOncology research2024

MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1.

Hui Sun, Masanori Kawano, Tatsuya Iwasaki, Ichiro Itonaga, Yuta Kubota, Hiroshi Tsumura, Kazuhiro Tanaka

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hui SunDepartment of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, 879-5503, Japan.
Masanori KawanoDepartment of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, 879-5503, Japan.
Tatsuya IwasakiDepartment of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, 879-5503, Japan.
Ichiro ItonagaDepartment of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, 879-5503, Japan.
Yuta KubotaDepartment of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, 879-5503, Japan.
Hiroshi TsumuraDepartment of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, 879-5503, Japan.
Kazuhiro TanakaDepartment of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, 879-5503, Japan.
Oita University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An important factor in the emergence and progression of osteosarcoma (OS) is the dysregulated expression of microRNAs (miRNAs). Transcription factor 7-like 1 (TCF7L1), a member of the T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factor family, interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding protein. This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in all examined OS cell lines. Additionally, a clinical comparison study was performed using the TCGA database. Subsequently, the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through

Indexed as

Bone NeoplasmsMicroRNAsOsteosarcomaTranscription Factor 7-Like 1 ProteinWnt Signaling PathwayAnimalsbeta CateninCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMiceMice, Nudebeta CateninMicroRNAsMIRN329 microRNA, humanTCF7L1 protein, humanTranscription Factor 7-Like 1 ProteinMiR-329-3pOsteosarcomaProliferationTCF7L1Wnt/β-catenin pathway

Identifiers

PMID38370338
PMCPMC10874473
OpenAlexW4390820231

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.