ArticlemedRxiv : the preprint server for health sciences2024
Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium.
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Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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80 authors at 20 institutions in 13 countries.
Jelle LamsmaDepartment of Criminology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Adrian RaineDepartment of Criminology, University of Pennsylvania, Philadelphia, USA.
Seyed M KiaDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.
Wiepke CahnDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.
Dominic AroldDivision of Psychological and Social Medicine and Developmental Neurosciences, TU Dresden, Germany.
Nerisa BanajLaboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, Rome, Italy.
Annarita BaroneDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Katharina BroschDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Rachel BrouwerDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.
Arturo BrunettiDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Vince D CalhounTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology and Emory University, Atlanta, USA.
Qian H ChewDepartment of Research, Institute of Mental Health, Singapore.
Sunah ChoiDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.
Young-Chul ChungDepartment of Psychiatry, Jeonbuk National University, Jeonju, South Korea.
Mariateresa CiccarelliDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Derin CobiaDepartment of Psychology and Neuroscience Center, Brigham Young University, Provo, USA.
Sirio CocozzaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Paola DazzanInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Andrea de BartolomeisDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Marta Di FortiInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Alexandre DumaisDepartment of Psychiatry and Addictology, University of Montreal, Montreal, Canada.
Jesse T EdmondTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology and Emory University, Atlanta, USA.
Stefan EhrlichDivision of Psychological and Social Medicine and Developmental Neurosciences, TU Dresden, Germany.
Ulrika EvermannDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Kira FlinkenflügelInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Foivos GeorgiadisDepartment of Psychiatry, Psychotherapy and Psychosomatics, University of Zürich, Switzerland.
David C GlahnDepartment of Psychiatry, Harvard Medical School, Harvard, USA.
Janik GoltermannInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Melissa J GreenNeuroscience Research Australia, Randwick, Australia.
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Amalia Guerrero-PedrazaHospital Benito Menni CASM, Barcelona, Spain.
Minji HaDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.
Elliot L HongDepartment of Psychiatry and Behavioral Science, UTHealth Houston, Houston, USA.
Hilleke Hulshoff PolDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.
Felice IasevoliDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Stefan KaiserDepartment of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland.
Vasily KaledaDepartment of Youth Psychiatry, Mental Health Research Center, Moscow, Russia.
Andriana KarukFIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.
Minah KimDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
Tilo KircherDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Matthias KirschnerDepartment of Psychiatry, Psychotherapy and Psychosomatics, University of Zürich, Switzerland.
Peter KochunovDepartment of Psychiatry and Behavioral Science, UTHealth Houston, Houston, USA.
Jun Soo KwonDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.
Irina LebedevaLaboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia.
Rebekka LencerInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Tiago R MarquesInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Susanne MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Robin MurrayInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Igor NenadićDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Dana NguyenDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine, USA.
Godfrey PearlsonOlin Neuropsychiatry Research Center, Institute of Living, Hartford, USA.
Fabrizio PirasLaboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, Rome, Italy.
Edith Pomarol-ClotetFIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.
Giuseppe PontilloDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Stéphane PotvinDepartment of Psychiatry and Addictology, University of Montreal, Montreal, Canada.
Adrian PredaDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine, USA.
Yann QuidéNeuroscience Research Australia, Randwick, Australia.
Amanda RodrigueDepartment of Psychiatry, Harvard Medical School, Harvard, USA.
Kelly Rootes-MurdyTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology and Emory University, Atlanta, USA.
Raymond SalvadorFIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.
Antonin SkochNational Institute of Mental Health, Klecany, Czech Republic.
Kang SimDepartment of Research, Institute of Mental Health, Singapore.
Gianfranco SpallettaLaboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, Rome, Italy.
Filip SpanielNational Institute of Mental Health, Klecany, Czech Republic.
Frederike SteinDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Florian Thomas-OdenthalDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Andràs TikàszDepartment of Psychiatry and Addictology, University of Montreal, Montreal, Canada.
David TomecekNational Institute of Mental Health, Klecany, Czech Republic.
Alexander TomyshevLaboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia.
Mario TranfaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Uyanga TsogtDepartment of Psychiatry, Jeonbuk National University, Jeonju, South Korea.
Jessica A TurnerPsychiatry and Behavioral Health, Ohio State University Wexner Medical Center, Columbus, USA.
Theo G M van ErpDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine, USA.
Neeltje E M van HarenDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.
Jim van OsDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.
Daniela VecchioLaboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, Rome, Italy.
Lei WangPsychiatry and Behavioral Health, Ohio State University Wexner Medical Center, Columbus, USA.
Adrian WroblewskiDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Thomas Nickl-JockschatDepartment of Psychiatry, University of Iowa, Iowa City, USA.
University of Naples Federico II · ITPhilipps University of Marburg · DEUniversity of Münster · DEKing's College London · GBFondazione Santa Lucia · ITSeoul National University · KRUniversity Medical Center Utrecht · NLGeorgia Institute of Technology · USMental Health Research Center of Russian Academy of Medical Sciences · RUUniversity of California, Irvine · USHarvard University · USInstitute of Mental Health · SGInstituto de Salud Carlos III · ESInstitut Universitaire en Santé Mentale de Québec · CANational Institute of Mental Health · CZTechnische Universität Dresden · DEThe University of Texas Health Science Center at Houston · USUNSW Sydney · AUBrigham Young University · USCzech Academy of Sciences · CZ
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MSOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0MENIGMA-COINSTAC-APOE2 Functional and structural connectome protective mechanisms for Alzheimer’s disease and mood disorders: Request for supplemental funds for NIH R01:1R01MH121246R01MH121246 · NIMH · OHIO STATE UNIVERSITY · PI CALHOUN, VINCE D, TURNER, JESS · 2019 to 2023
$5.0MAmish Connectome Project on Mental IllnessU01MH108148 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2015 to 2018
$4.3MTowards Multisystem-Brain Successful Aging in Schizophrenia SpectrumR01MH116948 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HONG, L ELLIOT ELLIOT · 2018 to 2022
$3.7MThe Vascular Axis in Schizophrenia Brain-Body AgingR01MH133812 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI L Elliot Elliot Hong · 2024 to 2026
$2.2MRedefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine LearningRF1MH123163 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V., THOMPSON, PAUL M · 2021 to 2021
$1.2MHybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593kNIBIB NIH HHS R01 EB015611NIBIB NIH HHS U54 EB020403NIH HHS S10 OD023696NIMH NIH HHS R01 MH116948NIMH NIH HHS R01 MH121246NIMH NIH HHS R01 MH133812NIMH NIH HHS RF1 MH123163NIMH NIH HHS U01 MH108148
Abstract
Background: Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited by group-level analyses, small and selective samples of inpatients and long time lags between exposure and outcome. Methods: This cross-sectional study pooled data from 20 sites participating in the international ENIGMA-Schizophrenia Working Group. Sites acquired T Results: Aggressive behaviour was significantly associated with reductions in total cortical volume (OR [99% CI] = 0.88 [0.78, 0.98], Conclusions: This study provides evidence that the co-occurrence of positive symptoms, poor impulse control and aggressive behaviour in schizophrenia has a neurobiological basis, which may inform the development of therapeutic interventions.
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