Evidence map›Paper›PMID 38372140›Full record

ReviewHypertension (Dallas, Tex. : 1979)2024

Milestone Papers on Signal Transduction Mechanisms of Hypertension and Its Complications.

Satoru Eguchi, Keiichi Torimoto, Adebowale Adebiyi, Praghalathan Kanthakumar, Gisele F Bomfim, Camilla Ferreira Wenceslau, Shelby A Dahlen, Patrick Osei-Owusu

Open access · greenAbstract readReview
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Satoru EguchiDepartment of Cardiovascular Science, Lewis Katz School of Medicine (S.E., K.T.), Temple University, Philadelphia, PA.ORCID 0000-0002-8407-7501
Keiichi TorimotoDepartment of Cardiovascular Science, Lewis Katz School of Medicine (S.E., K.T.), Temple University, Philadelphia, PA.ORCID 0000-0002-5174-5980
Adebowale AdebiyiDepartment of Medical Pharmacology and Physiology (A.A., P.K.), University of Missouri, Columbia.ORCID 0000-0002-7033-1871
Praghalathan KanthakumarDepartment of Medical Pharmacology and Physiology (A.A., P.K.), University of Missouri, Columbia.ORCID 0000-0002-7610-8945
Gisele F BomfimDepartment of Cell Biology and Anatomy, Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia (G.F.B., C.F.W.).ORCID 0000-0001-5528-0028
Camilla Ferreira WenceslauDepartment of Cell Biology and Anatomy, Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia (G.F.B., C.F.W.).ORCID 0000-0002-0815-3568
Shelby A DahlenDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH (S.A.D., P.O.-O.).ORCID 0000-0002-3430-2598
Patrick Osei-OwusuDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH (S.A.D., P.O.-O.).ORCID 0000-0002-4581-7044
Case Western Reserve University · USTemple University · USUniversity of Missouri Health System · USUniversity of South Carolina · US

Funding

Urotensin II and renal insufficiency in growth-restricted infants.R01DK127625 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI ADEBIYI, ADEBOWALE · 2020 to 2024
$3.0M
Vascular ion channels and microcirculation in neonatal urinary tract obstructionR01DK120595 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI ADEBIYI, ADEBOWALE · 2020 to 2024
$2.7M
Roles of aging and cellular senescence in the development of intracranial aneurysm ruptureR01AG077780 · NIA · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI SATORU EGUCHI, TOMOKI HASHIMOTO · 2023 to 2026
$2.4M
Control of microvascular function by ion channelsR01HL151735 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI ADEBIYI, ADEBOWALE · 2020 to 2023
$2.0M
Formyl peptide receptor activation induces vascular plasticity and remodeling inhypertensionR01HL149762 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WENCESLAU, CAMILLA FERREIRA · 2021 to 2025
$1.9M
Mechanism of Hypertensive Vascular Remodeling and End-Organ DamageR01HL133248 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI EGUCHI, SATORU · 2016 to 2019
$1.8M
Vascular Pyruvate Kinase M2 in HypertensionR01HL174004 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI SATORU EGUCHI, Patrick Osei-Owusu · 2025 to 2026
$1.4M
Mechanisms of Impaired Renal Hemodynamics after Spinal Cord InjuryR56DK132859 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI OSEI-OWUSU, PATRICK · 2022 to 2022
$100k
NHLBI NIH HHS R01 HL133248NHLBI NIH HHS R01 HL149762NHLBI NIH HHS R01 HL151735NHLBI NIH HHS R01 HL174004NIA NIH HHS R01 AG077780NIDDK NIH HHS R01 DK120595NIDDK NIH HHS R01 DK127625NIDDK NIH HHS R56 DK132859
6 · The paper itself

Abstract

To celebrate 100 years of American Heart Association-supported cardiovascular disease research, this review article highlights milestone papers that have significantly contributed to the current understanding of the signaling mechanisms driving hypertension and associated cardiovascular disorders. This article also includes a few of the future research directions arising from these critical findings. To accomplish this important mission, 4 principal investigators gathered their efforts to cover distinct yet intricately related areas of signaling mechanisms pertaining to the pathogenesis of hypertension. The renin-angiotensin system, canonical and novel contractile and vasodilatory pathways in the resistance vasculature, vascular smooth muscle regulation by membrane channels, and noncanonical regulation of blood pressure and vascular function will be described and discussed as major subjects.

Indexed as

Cardiovascular SystemHypertensionAngiotensin IIBlood PressureHumansRenin-Angiotensin SystemSignal TransductionAngiotensin IIangiotensin IIendoplasmic reticulum stression channelsmicrobiotatoll-like receptors

Identifiers

PMID38372140
PMCPMC11023792
OpenAlexW4391947823

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.