Evidence map›Paper›PMID 38374262›Full record

ArticleNature methods2024

Multimodal probing of T-cell recognition with hexapod heterostructures.

Xiaodan Huang, Lingyuan Meng, Guoshuai Cao, Aleksander Prominski, Yifei Hu, Chuanwang Yang, Min Chen, Jiuyun Shi, Charles Gallagher, Thao Cao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaodan Huang *Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.
Lingyuan Meng *Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-1690-586X
Guoshuai CaoPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9987-4554
Aleksander ProminskiDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Yifei HuPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2870-7772
Chuanwang YangThe James Franck Institute, University of Chicago, Chicago, IL, USA.
Min ChenPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.
Jiuyun ShiDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Charles GallagherDepartment of Physics, University of Chicago, Chicago, IL, USA.
Thao CaoPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.
Jiping YueDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Jun HuangPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA. huangjun@uchicago.edu.ORCID http://orcid.org/0000-0003-0271-4384
Bozhi TianDepartment of Chemistry, University of Chicago, Chicago, IL, USA. btian@uchicago.edu.ORCID http://orcid.org/0000-0003-0593-0023

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
Medical Scientist National Research Service AwardT32GM150375 · NIGMS · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2023 to 2026
$5.5M
National Science Foundation (NSF) DMR-2011854NIGMS NIH HHS T32 GM007281NIGMS NIH HHS T32 GM150375
6 · The paper itself

Abstract

Studies using antigen-presenting systems at the single-cell and ensemble levels can provide complementary insights into T-cell signaling and activation. Although crucial for advancing basic immunology and immunotherapy, there is a notable absence of synthetic material toolkits that examine T cells at both levels, and especially those capable of single-molecule-level manipulation. Here we devise a biomimetic antigen-presenting system (bAPS) for single-cell stimulation and ensemble modulation of T-cell recognition. Our bAPS uses hexapod heterostructures composed of a submicrometer cubic hematite core (α-Fe

Indexed as

Lymphocyte ActivationT-LymphocytesAnimalsAntigen PresentationAntigen-Presenting CellsFerric CompoundsHumansMiceNanostructuresPeptidesReceptors, Antigen, T-CellReceptors, Chimeric AntigenSilicon DioxideFerric CompoundsPeptidesReceptors, Antigen, T-CellReceptors, Chimeric AntigenSilicon Dioxide

Identifiers

PMID38374262
PMCPMC11723587

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.