Evidence map›Paper›PMID 38375039›Full record

ReviewFrontiers in pharmacology2024

Systematic review of melatonin in cerebral ischemia-reperfusion injury: critical role and therapeutic opportunities.

Chenguang Zhang, Yumei Ma, Yating Zhao, Na Guo, Chen Han, Qian Wu, Changqing Mu, Yue Zhang, Shutong Tan, Jian Zhang and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chenguang Zhang *Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Yumei Ma *Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Yating ZhaoDepartment of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Na GuoDepartment of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Chen HanDepartment of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Qian WuDepartment of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Changqing MuDepartment of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Yue ZhangDepartment of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Shutong TanDepartment of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Jian ZhangDepartment of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Shenyang, Liaoning, China.
Xu LiuDepartment of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral ischemia-reperfusion (I/R) injury is the predominant causes for the poor prognosis of ischemic stroke patients after reperfusion therapy. Currently, potent therapeutic interventions for cerebral I/R injury are still very limited. Melatonin, an endogenous hormone, was found to be valid in preventing I/R injury in a variety of organs. However, a systematic review covering all neuroprotective effects of melatonin in cerebral I/R injury has not been reported yet. Thus, we perform a comprehensive overview of the influence of melatonin on cerebral I/R injury by collecting all available literature exploring the latent effect of melatonin on cerebral I/R injury as well as ischemic stroke. In this systematic review, we outline the extensive scientific studies and summarize the beneficial functions of melatonin, including reducing infarct volume, decreasing brain edema, improving neurological functions and attenuating blood-brain barrier breakdown, as well as its key protective mechanisms on almost every aspect of cerebral I/R injury, including inhibiting oxidative stress, neuroinflammation, apoptosis, excessive autophagy, glutamate excitotoxicity and mitochondrial dysfunction. Subsequently, we also review the predictive and therapeutic implications of melatonin on ischemic stroke reported in clinical studies. We hope that our systematic review can provide the most comprehensive introduction of current advancements on melatonin in cerebral I/R injury and new insights into personalized diagnosis and treatment of ischemic stroke.

Indexed as

cerebral ischemia-reperfusion injuryischemic strokemelatoninneuroprotectionsystematic review

Identifiers

PMID38375039
PMCPMC10875093

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.