PKCμ promotes keratinocyte cell migration through Cx43 phosphorylation-mediated suppression of intercellular communication.

Renju Pun, Ann M Cavanaugh, Emily Aldrich, Olivia Tran, Justin C Rudd, Laura A Hansen, Brian J North

Abstract read

In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Sub-millivolt voltage imaging reveals gap junction-mediated bioelectric contact inhibition.Nature communications · 2026
Article
Connexin 32 constrains a mesenchymal-like switch in differentiated urothelium and luminal cancers.Life science alliance · 2026
Article
The relationship between Connexin 43 (Cx43) and partner protein, human discs large homologue-1 (Dlg1) during wound closure in keratinocytes.Cell and tissue research · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Renju PunBiomedical Sciences Department, School of Medicine, Creighton University, Omaha, NE 68178, USA.

Ann M CavanaughDepartment of Biology, College of Arts and Sciences, Creighton University, Omaha, NE 68178, USA.

Emily AldrichBiomedical Sciences Department, School of Medicine, Creighton University, Omaha, NE 68178, USA.

Olivia TranBiomedical Sciences Department, School of Medicine, Creighton University, Omaha, NE 68178, USA.

Justin C RuddBiomedical Sciences Department, School of Medicine, Creighton University, Omaha, NE 68178, USA.

Laura A HansenBiomedical Sciences Department, School of Medicine, Creighton University, Omaha, NE 68178, USA.

Brian J NorthBiomedical Sciences Department, School of Medicine, Creighton University, Omaha, NE 68178, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Downregulation of intercellular communication through suppression of gap junctional conductance is necessary during wound healing. Connexin 43 (Cx43), a prominent gap junction protein in skin, is downregulated following wounding to restrict communication between keratinocytes. Previous studies found that PKCμ, a novel PKC isozyme, regulates efficient cutaneous wound healing. However, the molecular mechanism by which PKCμ regulates wound healing remains unknown. We have identified that PKCμ suppresses intercellular communication and enhances cell migration in an

Indexed as

Biological sciencesCell biologyMolecular biologyMolecular interaction

Identifiers

PMID38375220

DOI10.1016/j.isci.2024.109033

PMCPMC10875573

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.