Evidence mapPaperPMID 38379409Full record

ArticleBiological chemistry2024

Biochemical evidence for conformational variants in the anti-viral and pro-metastatic protein IFITM1.

Marta Nekulová, Marta Wyszkowska, Nela Friedlová, Lukáš Uhrík, Filip Zavadil Kokáš, Václav Hrabal, Lenka Hernychová, Bořivoj Vojtěšek, Ted R Hupp, Michał R Szymański

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Article in Biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marta NekulováResearch Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.ORCID 0000-0001-6404-2566
Marta WyszkowskaStructural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk, 80-307 Gdansk, Poland.
Nela FriedlováResearch Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Lukáš UhríkResearch Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Filip Zavadil KokášResearch Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Václav HrabalResearch Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Lenka HernychováResearch Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Bořivoj VojtěšekResearch Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Ted R HuppInstitute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XR Edinburgh, UK.
Michał R SzymańskiStructural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk, 80-307 Gdansk, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interferon induced transmembrane proteins (IFITMs) play a dual role in the restriction of RNA viruses and in cancer progression, yet the mechanism of their action remains unknown. Currently, there is no data about the basic biochemical features or biophysical properties of the IFITM1 protein. In this work, we report on description and biochemical characterization of three conformational variants/oligomeric species of recombinant IFITM1 protein derived from an

Indexed as

Antigens, DifferentiationProtein ConformationAntiviral AgentsHumansRecombinant ProteinsAntigens, DifferentiationAntiviral Agentsleu-13 antigenRecombinant Proteinshydrogen deuterium exchangeIFITM proteinsoligomerizationprotein conformationprotein structure

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.