Evidence map›Paper›PMID 38381238›Full record

ArticlePituitary2024

Glucose intolerance in acromegaly is driven by low insulin secretion; results from an intravenous glucose tolerance test.

Laura Georgiana Zaifu, Dan Alexandru Niculescu, Andreea Elena Kremer, Andra Caragheorgheopol, Mariana Sava, Carmen Nicoleta Iordachescu, Roxana Dusceac, Iulia Florentina Burcea, Catalina Poiana

Abstract read
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In one paragraph

Article in Pituitary, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Laura Georgiana ZaifuDepartment of Endocrinology, Carol Davila University of Medicine and Pharmacy, 34-38 Aviatorilor blvd, Bucharest, 011863, Romania.
Dan Alexandru NiculescuDepartment of Endocrinology, Carol Davila University of Medicine and Pharmacy, 34-38 Aviatorilor blvd, Bucharest, 011863, Romania. dan.niculescu@umfcd.ro.ORCID http://orcid.org/0000-0002-6439-3523
Andreea Elena KremerResearch Laboratory, C. I. Parhon National Institute of Endocrinology, Bucharest, Romania.
Andra CaragheorgheopolResearch Laboratory, C. I. Parhon National Institute of Endocrinology, Bucharest, Romania.
Mariana SavaClinical Laboratory, C. I. Parhon National Institute of Endocrinology, Bucharest, Romania.
Carmen Nicoleta IordachescuClinical Laboratory, C. I. Parhon National Institute of Endocrinology, Bucharest, Romania.
Roxana DusceacFirst Endocrinology Department, C. I. Parhon National Institute of Endocrinology, Bucharest, Romania.
Iulia Florentina BurceaDepartment of Endocrinology, Carol Davila University of Medicine and Pharmacy, 34-38 Aviatorilor blvd, Bucharest, 011863, Romania.
Catalina PoianaDepartment of Endocrinology, Carol Davila University of Medicine and Pharmacy, 34-38 Aviatorilor blvd, Bucharest, 011863, Romania.
Institutul Național de Endocrinologie C.I. Parhon · ROCarol Davila University of Medicine and Pharmacy · RO

Funding

Carol Davila University of Medicine and Pharmacy Young Researchers 28332/04.11.2013Pfizer 57404559/11.11.2019
6 · The paper itself

Abstract

purposeInsulin sensitivity (S

methodsWe performed an IVGTT in 25 patients with active acromegaly (13 normal glucose tolerance [NGT], 6 impaired glucose tolerance [IGT] and 6 diabetes mellitus [DM]) and 23 controls (8 lean NGT, 8 obese NGT and 7 obese IGT). Serum glucose and insulin were measured at 20 time points along the test to calculate S

resultsIn acromegaly, patients with NGT had significantly (p for trend < 0.001) higher AIRg (3383 ± 1082 pmol*min/L) than IGT (1215 ± 1069) and DM (506 ± 600). AIRg was higher in NGT (4764 ± 1180 pmol*min/L) and IGT (3183 ± 3261) controls with obesity than NGT (p = 0.01) or IGT (p = 0.17) acromegaly. S

conclusionWe demonstrated that low insulin secretion is the main driver behind glucose intolerance in acromegaly. Compared to NGT and IGT controls with obesity, patients with NGT or IGT acromegaly had higher S

Indexed as

AcromegalyGlucose IntoleranceInsulin ResistanceBlood GlucoseDiabetes MellitusGlucoseGlucose Tolerance TestHumansInsulinInsulin SecretionObesityBlood GlucoseGlucoseInsulinAcromegalyDisposition indexGlucose intoleranceInsulin secretionInsulin sensitivity

Identifiers

PMID38381238
OpenAlexW4391999343

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.