Evidence map›Paper›PMID 38385184›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024

Serotonin therapies for opioid-induced disordered swallow and respiratory depression.

Michael Frazure, In Morimoto, Nathan Fielder, Nicholas Mellen, Kimberly Iceman, Teresa Pitts

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Michael FrazureDepartment of Physiology, School of Medicine, University of Louisville, Louisville, Kentucky, United States.ORCID 0000-0002-8775-7692
In MorimotoDepartment of Mechanical and Intelligent Systems Engineering, The University of Electro-Communications, Tokyo, Japan.
Nathan FielderSchool of Medicine, University of Louisville, Louisville, Kentucky, United States.
Nicholas MellenDepartment of Neurology, School of Medicine, University of Louisville, Louisville, Kentucky, United States.
Kimberly IcemanDepartment of Speech, Language, and Hearing Sciences and Dalton Cardiovascular Center, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0002-9004-3893
Teresa PittsDepartment of Speech, Language, and Hearing Sciences and Dalton Cardiovascular Center, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0001-9448-2175
University of Louisville · USUniversity of Missouri · USUniversity of Electro-Communications · JP

Funding

Central and Peripheral Regulation of Laryngeal AdductionR01HL163008 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, PITTS, TERESA G · 2022 to 2025
$2.8M
Influence of Opioids on the Brainstem Respiratory NetworkR01HL155721 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, MORRIS, KENDALL FRANCIS · 2021 to 2024
$2.7M
Regulation of swallow and the effects of high cervical spinal cord injuryR01NS110169 · NINDS · UNIVERSITY OF LOUISVILLE · PI PITTS, TERESA G · 2019 to 2023
$1.7M
Delineating impacts of gestational opioid exposure on central swallow networks.R21HD110951 · NICHD · UNIVERSITY OF MISSOURI-COLUMBIA · PI PITTS, TERESA G · 2023 to 2024
$411k
NHLBI NIH HHS R01 HL155721NHLBI NIH HHS R01 HL163008NICHD NIH HHS R21 HD110951NINDS NIH HHS R01 NS110169
6 · The paper itself

Abstract

Opioids are well-known to cause respiratory depression, but despite clinical evidence of dysphagia, the effects of opioids on swallow excitability and motor pattern are unknown. We tested the effects of the clinically relevant opioid buprenorphine on pharyngeal swallow and respiratory drive in male and female rats. We also evaluated the utility of 5-HT

Indexed as

BuprenorphineDeglutition DisordersRespiratory Insufficiency8-Hydroxy-2-(di-n-propylamino)tetralinAnalgesics, OpioidAnimalsBuspironeFemaleMaleRatsRats, Sprague-DawleySerotonin8-Hydroxy-2-(di-n-propylamino)tetralinAnalgesics, OpioidBuprenorphineBuspironeSerotonin5-HT1Abreathingbuprenorphinesurvivalswallow

Identifiers

PMID38385184
PMCPMC11286276
OpenAlexW4392057645

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.