Evidence map›Paper›PMID 38385293›Full record

ReviewArteriosclerosis, thrombosis, and vascular biology2024

Calcium Signaling in Airway Epithelial Cells: Current Understanding and Implications for Inflammatory Airway Disease.

Amit Jairaman, Murali Prakriya

Open access · greenAbstract readReview
In one paragraph

Review in Arteriosclerosis, thrombosis, and vascular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
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  4. A novel role ofMicrobiology spectrum · 2026
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  19. Association of dietary calcium intake with chronic bronchitis and emphysema.Journal of health, population, and nutrition · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Amit JairamanDepartment of Physiology and Biophysics, School of Medicine, University of California-Irvine (UCI) (A.J.).ORCID 0000-0002-5206-700X
Murali PrakriyaDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL (M.P.).ORCID 0000-0003-0781-4480
Northwestern University · USUniversity of California, Irvine · US

Funding

Store-Operated Channels in the Nervous SystemR01NS057499 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2007 to 2022
$5.4M
The Physiology of Store-Operated Channels in the Nervous SystemR35NS132349 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Murali Prakriya · 2023 to 2026
$3.7M
Regulation of airway epithelial cell-mediated inflammation by CRAC channelsR01HL149385 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2019 to 2022
$1.9M
NHLBI NIH HHS R01 HL149385NINDS NIH HHS R01 NS057499NINDS NIH HHS R35 NS132349
6 · The paper itself

Abstract

Airway epithelial cells play an indispensable role in protecting the lung from inhaled pathogens and allergens by releasing an array of mediators that orchestrate inflammatory and immune responses when confronted with harmful environmental triggers. While this process is undoubtedly important for containing the effects of various harmful insults, dysregulation of the inflammatory response can cause lung diseases including asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. A key cellular mechanism that underlies the inflammatory responses in the airway is calcium signaling, which stimulates the production and release of chemokines, cytokines, and prostaglandins from the airway epithelium. In this review, we discuss the role of major Ca

Indexed as

AsthmaCalcium SignalingEpithelial CellsHumansInflammationLungasthmacalcium signalingchemokinecytokineepitheliuminflammationion channels

Identifiers

PMID38385293
PMCPMC11090472
OpenAlexW4392050730

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.