ArticleNature metabolism2024
Enteric and systemic postprandial lactate shuttle phases and dietary carbohydrate carbon flow in humans.
Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back-to-Back Neuroimaging and Blood Analysis.Magnetic resonance in medicine · 2026Article
- Hyperlactatemia and pulmonary gas exchange at rest and during exercise: lessons from patients on metformin.European journal of applied physiology · 2026Article
- Integrative Bioinformatics and Experimental Validation Identify LOX as a Glycolysis-Related Biomarker in Myocardial Ischemia-Reperfusion Injury.Cardiovascular toxicology · 2026Article
- Circadian biology and exercise: the time to move.Life metabolism · 2026Review
- Lactylation enzymes in cancer: Mechanisms and novel therapeutic approaches (Review).Oncology letters · 2026Review
- Measurement of glycolysis with heavy water labeling.The Journal of biological chemistry · 2026Article
- Molecular vehicles for therapeutic delivery of lactate in exercise and medicine.Sports medicine and health science · 2026Review
- Exploring UVA1-Induced Metabolic Effects in Different In Vitro, Ex Vivo, and In Vivo Systems.Metabolites · 2026Article
- L-lactic acid enhances type I interferon immune response and inhibits virus infection by promoting IRF9 L-lactylation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Lactate metabolism is exploited bymBio · 2025Article
- Postprandial Metabolism, Inflammation, and Plasma Bile Acid Kinetics in a Rat Model: Implications for Translational Research.Molecular nutrition & food research · 2025Article
- Inhibition of LDHB triggers DNA damage and increases cisplatin sensitivity in pleural mesothelioma.Oncogenesis · 2025Article
- Increasing the health span: unique role for exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Tumor Microenvironment Lactate: Is It a Cancer Progression Marker, Immunosuppressant, and Therapeutic Target?Molecules (Basel, Switzerland) · 2025Review
- Lactate homeostasis is maintained through regulation of glycolysis and lipolysis.Cell metabolism · 2025Article
- The mitochondrial lactate oxidation complex: endpoint for carbohydrate carbon disposal.American journal of physiology. Endocrinology and metabolism · 2025Article
- Aging delays the suppression of lipolysis and fatty acid oxidation in the postprandial period.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Leg cycling efficiency is unaltered in healthy aging regardless of sex or training status.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Delayed and diminished postprandial lactate shuttling in healthy older men and women.American journal of physiology. Endocrinology and metabolism · 2024Article
- Altered glucose kinetics occurs with aging: a new outlook on metabolic flexibility.American journal of physiology. Endocrinology and metabolism · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Dietary glucose in excess is stored in the liver in the form of glycogen. As opposed to direct conversion of glucose into glycogen, the hypothesis of the postprandial lactate shuttle (PLS) proposes that dietary glucose uptake is metabolized to lactate in the gut, thereby being transferred to the liver for glycogen storage. In the present study, we provide evidence of a PLS in young healthy men and women. Overnight fasted participants underwent an oral glucose tolerance test, and arterialized lactate concentration and rate of appearance were determined. The concentration of lactate in the blood rose before the concentration of glucose, thus providing evidence of an enteric PLS. Secondary increments in the concentration of lactate in the blood and its rate of appearance coincided with those of glucose, which indicates the presence of a larger, secondary, systemic PLS phase driven by hepatic glucose release. The present study challenges the notion that lactate production is the result of hypoxia in skeletal muscles, because our work indicates that glycolysis proceeds to lactate in fully aerobic tissues and dietary carbohydrate is processed via lactate shuttling. Our study proposes that, in humans, lactate is a major vehicle for carbohydrate carbon distribution and metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.