Evidence map›Paper›PMID 38391718›Full record

ArticleBrain sciences2024

Coexisting Biopsy-Diagnosed Dementia and Glioblastoma.

Kaleigh Fetcko-Fayad, Kristen Batich, Zachary J Reitman, Kyle M Walsh, Gregory Chamberlin, Vanessa Smith, Karra Jones, Thomas Cummings, Katherine B Peters

Abstract readCase Reports
In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma.Journal of cellular and molecular medicine · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaleigh Fetcko-FayadDepartment of Neurosurgery, Neuro-Oncology, Duke University Medical Center, Durham, NC 27710, USA.
Kristen BatichDepartment of Neurosurgery, Neuro-Oncology, Duke University Medical Center, Durham, NC 27710, USA.
Zachary J ReitmanDepartment of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-9122-9550
Kyle M WalshDepartment of Neurosurgery, Neuro-Epidemiology, Duke University Medical Center, Durham, NC 27710, USA.
Gregory ChamberlinDepartment of Pathology, Clinical Pathology Services, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0003-4306-3549
Vanessa SmithDepartment of Pathology, Clinical Pathology Services, Duke University Medical Center, Durham, NC 27710, USA.
Karra JonesDepartment of Pathology, Clinical Pathology Services, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-8819-8992
Thomas CummingsDepartment of Pathology, Clinical Pathology Services, Duke University Medical Center, Durham, NC 27710, USA.
Katherine B PetersDepartment of Neurosurgery, Neuro-Oncology, Duke University Medical Center, Durham, NC 27710, USA.

Funding

Research Education Component CoreP30AG072958 · NIA · DUKE UNIVERSITY · PI Maria Marquine · 2021 to 2026
$24.1M
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATMK08CA256045 · NCI · DUKE UNIVERSITY · PI Zachary Reitman · 2022 to 2026
$1.1M
NCI NIH HHS K08 CA256045NIA NIH HHS P30 AG072958NIGMS NIH HHS T32 GM145449
6 · The paper itself

Abstract

Both glioblastoma (GBM) and dementia are devastating diseases with limited treatments that are usually not curative. Having clinically diagnosed dementia with an associated biopsy-proven etiology and a coexisting GBM diagnosis is a rare occurrence. The relationship between the development of neurodegenerative dementia and GBM is unclear, as there are conflicting reports in the literature. We present two cases of simultaneous biopsy-proven dementia, one with Alzheimer's disease (AD) and GBM, and one with cerebral amyloid angiopathy (CAA) and GBM. We discuss how these diseases may be associated. Whether one pathologic process begins first or develops concurrently is unknown, but certain molecular pathways of dementia and GBM appear directly related while others inversely related. Further investigations of these close molecular relationships between dementia and GBM could lead to development of improved diagnostic tools and therapeutic interventions for both diseases.

Indexed as

Alzheimer’s diseasecerebral amyloid angiopathydementiaglioblastoma

Identifiers

PMID38391718
PMCPMC10886654

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.