Evidence map›Paper›PMID 38396205›Full record

ArticleScientific reports2024

Metabolomic associations of impaired awareness of hypoglycaemia in type 1 diabetes.

R D M Varkevisser, A Cecil, C Prehn, D Mul, H J Aanstoot, A D Paterson, B H R Wolffenbuttel, M M van der Klauw

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

R D M VarkevisserDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. r.d.m.varkevisser@umcg.nl.
A CecilMetabolomic and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
C PrehnMetabolomic and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
D MulDiabeter Netherlands, Center for Type 1 Diabetes Care and Research, Rotterdam, The Netherlands.
H J AanstootDiabeter Netherlands, Center for Type 1 Diabetes Care and Research, Rotterdam, The Netherlands.
A D PatersonGenetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada.
B H R WolffenbuttelDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
M M van der KlauwDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Helmholtz Zentrum München · DEUniversity of Groningen · NLHospital for Sick Children · CAUniversity Medical Center Groningen · NL

Funding

Juvenile Diabetes Research Foundation 3-SRA-2014-291-M-R
6 · The paper itself

Abstract

This study investigates impaired awareness of hypoglycaemia (IAH), a complication of insulin therapy affecting 20-40% of individuals with type 1 diabetes. The exact pathophysiology is unclear, therefore we sought to identify metabolic signatures in IAH to elucidate potential pathophysiological pathways. Plasma samples from 578 individuals of the Dutch type 1 diabetes biomarker cohort, 67 with IAH and 108 without IAH (NAH) were analysed using the targeted metabolomics Biocrates AbsoluteIDQ p180 assay. Eleven metabolites were significantly associated with IAH. Genome-wide association studies of these 11 metabolites identified significant single nucleotide polymorphisms (SNPs) in C22:1-OH and phosphatidylcholine diacyl C36:6. After adjusting for the SNPs, 11 sphingomyelins and phosphatidylcholines were significantly higher in the IAH group in comparison to NAH. These metabolites are important components of the cell membrane and have been implicated to play a role in cell signalling in diabetes. These findings demonstrate the potential role of phosphatidylcholine and sphingomyelins in IAH.

Indexed as

Diabetes Mellitus, Type 1HypoglycemiaAwarenessGenome-Wide Association StudyHumansPhosphatidylcholinesSphingomyelinsPhosphatidylcholinesSphingomyelins

Identifiers

PMID38396205
PMCPMC10891160
OpenAlexW4392123390

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.