Evidence map›Paper›PMID 38396919›Full record

ArticleInternational journal of molecular sciences2024

7,8-Dihydroxy Efavirenz Is Not as Effective in CYP46A1 Activation In Vivo as Efavirenz or Its 8,14-Dihydroxy Metabolite.

Natalia Mast, Yong Li, Irina A Pikuleva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Natalia MastDepartment of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-6427-640X
Yong LiDepartment of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, USA.
Irina A PikulevaDepartment of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-9742-6232
Case Western Reserve University · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Cholesterol Metabolizing P450s: Structure and FunctionR01AG067552 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI PIKULEVA, IRINA A · 2020 to 2024
$2.2M
NEI NIH HHS EY011373NEI NIH HHS P30 EY011373NIA NIH HHS AG067552NIA NIH HHS R01 AG067552
6 · The paper itself

Abstract

High dose

Indexed as

Alzheimer DiseaseAnti-HIV AgentsHIV InfectionsAlkynesAmyloid beta-PeptidesAnimalsBenzoxazinesCholesterol 24-HydroxylaseCyclopropanesFemaleMaleMiceReverse Transcriptase InhibitorsAlkynesAmyloid beta-PeptidesAnti-HIV AgentsBenzoxazinesCholesterol 24-HydroxylaseCyclopropanesefavirenzReverse Transcriptase InhibitorsAlzheimer’s diseasebraincholesterolCYP46A1efavirenz(rac)-7,8dihydroxy efavirenz(rac)-8,14dihydroxy efavirenz

Identifiers

PMID38396919
PMCPMC10889178
OpenAlexW4391815331

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.