Evidence map›Paper›PMID 38397423›Full record

ArticleBiomolecules2024

Integrated Analysis of Gut Microbiome and Adipose Transcriptome Reveals Beneficial Effects of Resistant Dextrin from Wheat Starch on Insulin Resistance in Kunming Mice.

Xinyang Chen, Yinchen Hou, Aimei Liao, Long Pan, Shengru Yang, Yingying Liu, Jingjing Wang, Yingchun Xue, Mingyi Zhang, Zhitong Zhu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xinyang ChenFood Laboratory of Zhongyuan, Luohe 462300, China.
Yinchen HouFood Laboratory of Zhongyuan, Luohe 462300, China.ORCID 0000-0003-2779-3891
Aimei LiaoFood Laboratory of Zhongyuan, Luohe 462300, China.
Long PanFood Laboratory of Zhongyuan, Luohe 462300, China.ORCID 0000-0002-1149-8081
Shengru YangCollege of Food and Biological Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Yingying LiuFood Laboratory of Zhongyuan, Luohe 462300, China.
Jingjing WangFood Laboratory of Zhongyuan, Luohe 462300, China.
Yingchun XueFood Laboratory of Zhongyuan, Luohe 462300, China.
Mingyi ZhangFood Laboratory of Zhongyuan, Luohe 462300, China.
Zhitong ZhuFood Laboratory of Zhongyuan, Luohe 462300, China.
Jihong HuangFood Laboratory of Zhongyuan, Luohe 462300, China.ORCID 0000-0002-0754-409X
Henan University of Technology · CNHenan University of Economic and Law · CNHenan University · CN

Funding

Central Government Guides the Local Science and Technology Development Special Fund Z20221341069Henan Provincial Key Science&Technology Special Project 232102111060Key Research and Development Project of Henan Province 231111310700Major Science and Technology Projects for Public Welfare of Henan Province 201300110300Zhongyuan Scholars of Henan Province in China: 192101510004; Zhongyuan Scholar Workstation Funded Project ZYGZZ2021056,224400510026
6 · The paper itself

Abstract

Systemic chronic inflammation is recognized as a significant contributor to the development of obesity-related insulin resistance. Previous studies have revealed the physiological benefits of resistant dextrin (RD), including obesity reduction, lower fasting glucose levels, and anti-inflammation. The present study investigated the effects of RD intervention on insulin resistance (IR) in Kunming mice, expounding the mechanisms through the gut microbiome and transcriptome of white adipose. In this eight-week study, we investigated changes in tissue weight, glucose-lipid metabolism levels, serum inflammation levels, and lesions of epididymal white adipose tissue (eWAT) evaluated via Hematoxylin and Eosin (H&E) staining. Moreover, we analyzed the gut microbiota composition and transcriptome of eWAT to assess the potential protective effects of RD intervention. Compared with a high-fat, high-sugar diet (HFHSD) group, the RD intervention significantly enhanced glucose homeostasis (e.g., AUC-OGTT, HOMA-IR,

Indexed as

Animals, Outbred StrainsGastrointestinal MicrobiomeInsulin ResistanceAnimalsDextrinsGlucoseInflammationMiceMice, Inbred C57BLObesityPhosphatidylinositol 3-KinasesStarchTranscriptomeTriticumDextrinsGlucosePhosphatidylinositol 3-KinasesStarchgut microbiotainflammationinsulin resistanceresistant dextrintranscriptome

Identifiers

PMID38397423
PMCPMC10886926
OpenAlexW4391541237

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.