Evidence map›Paper›PMID 38397455›Full record

ArticleBiomolecules2024

Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells.

Pedro Barbosa, Aryane Pinho, André Lázaro, Diogo Paula, José G Tralhão, Artur Paiva, Maria J Pereira, Eugenia Carvalho, Paula Laranjeira

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Osteonecrosis of the Jaw in Post-Bariatric Patients: An Underestimated Risk in Oral Surgery? Clinical Implications and Perspectives.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Pedro BarbosaUniversity of Coimbra, Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), 3030-789 Coimbra, Portugal.ORCID 0000-0002-0048-2615
Aryane PinhoCenter for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, Portugal.
André LázaroGeneral Surgery Unit, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal.
Diogo PaulaGeneral Surgery Unit, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal.
José G TralhãoGeneral Surgery Unit, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal.
Artur PaivaCenter for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-504 Coimbra, Portugal.ORCID 0000-0002-6562-5859
Maria J PereiraDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, SE-75185 Uppsala, Sweden.ORCID 0000-0001-5498-3899
Eugenia CarvalhoCenter for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, Portugal.ORCID 0000-0001-6264-3632
Paula LaranjeiraCenter for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, Portugal.ORCID 0000-0002-1136-6118
Hospitais da Universidade de Coimbra · PTUniversity of Coimbra · PTUppsala University · SE

Funding

European Regional Development Fund through the Centro 2020 Regional Operational Programme Healthy Aging 2020- 803 CENTRO-01-0145-FEDER-000012EXODIAB (Excellence of Diabetes Research in Sweden) EXODIABFundação para a Ciência e Tecnologia LA/P/0058/2020Fundação para a Ciência e Tecnologia POCI-01-0145-FEDER-007440Fundação para a Ciência e Tecnologia SFRH/BD/143849/2019Fundação para a Ciência e Tecnologia SFRH/BD/145054/2019Fundação para a Ciência e Tecnologia UIDB/04539/2020Fundação para a Ciência e Tecnologia UIDP/04539/2020Rudberg Agnes and Mac Foundation Rudberg Agnes and Mac Foundation
6 · The paper itself

Abstract

Low-grade inflammation is closely linked to obesity and obesity-related comorbidities; therefore, immune cells have become an important topic in obesity research. Here, we performed a deep phenotypic characterization of circulating T cells in people with obesity, using flow cytometry. Forty-one individuals with obesity (OB) and clinical criteria for bariatric surgery were enrolled in this study. We identified and quantified 44 different circulating T cell subsets and assessed their activation status and the expression of immune-checkpoint molecules, immediately before (T1) and 7-18 months after (T2) the bariatric surgery. Twelve age- and sex-matched healthy individuals (nOB) were also recruited. The OB participants showed higher leukocyte counts and a higher percentage of neutrophils. The percentage of circulating Th1 cells were negatively correlated to HbA1c and insulin levels. OB Th1 cells displayed a higher activation status and lower PD-1 expression. The percentage of Th17 and Th1/17 cells were increased in OB, whereas the CD4

Indexed as

Bariatric SurgeryTh1 CellsHumansObesityT-Lymphocytes, RegulatoryT-Lymphocyte Subsetsbariatric surgeryimmune phenotypeinsulin resistanceobesityT cellsTreg

Identifiers

PMID38397455
PMCPMC10886753
OpenAlexW4391746437

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.