Evidence map›Paper›PMID 38398608›Full record

ArticleMolecules (Basel, Switzerland)2024

A Novel Antimicrobial Mechanism of Azalomycin F Acting on Lipoteichoic Acid Synthase and Cell Envelope.

Zilong Luo, Pingyi Li, Duoduo Zhang, Jianping Zhu, Wan Wang, Wenjia Zhao, Peibo Li, Ganjun Yuan

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zilong LuoBiotechnological Engineering Center for Pharmaceutical Research and Development, Jiangxi Agricultural University, Nanchang 330045, China.
Pingyi LiBiotechnological Engineering Center for Pharmaceutical Research and Development, Jiangxi Agricultural University, Nanchang 330045, China.
Duoduo ZhangBiotechnological Engineering Center for Pharmaceutical Research and Development, Jiangxi Agricultural University, Nanchang 330045, China.
Jianping ZhuLaboratory of Natural Medicine and Microbiological Drug, College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang 330045, China.
Wan WangSchool of Basic Medicine, Nanchang Medical College, Nanchang 330006, China.
Wenjia ZhaoBiotechnological Engineering Center for Pharmaceutical Research and Development, Jiangxi Agricultural University, Nanchang 330045, China.
Peibo LiSchool of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Ganjun YuanBiotechnological Engineering Center for Pharmaceutical Research and Development, Jiangxi Agricultural University, Nanchang 330045, China.ORCID 0000-0002-4944-1144
Jiangxi Agricultural University · CNSun Yat-sen University · CN

Funding

National Natural Science Foundation of China 81960636National Natural Science Foundation of China 82073745National Natural Science Foundation of China 82360691
6 · The paper itself

Abstract

Lipoteichoic acid (LTA) plays an essential role in bacterial growth and resistance to antibiotics, and LTA synthetase (LtaS) was considered as an attractive target for combating Gram-positive infections. Azalomycin F, a natural guanidyl-containing polyhydroxy macrolide, can target the LTA of

Indexed as

LipopolysaccharidesStaphylococcus aureusAnti-Bacterial AgentsCell MembraneMacrolidesTeichoic AcidsAnti-Bacterial Agentsazalomycin-FLipopolysaccharideslipoteichoic acidMacrolidesTeichoic Acidsazalomycin Ffluorescencelipoteichoic acidmolecular dockproteomicsStaphylococcus aureusvirulence factor

Identifiers

PMID38398608
PMCPMC10893547
OpenAlexW4391809605

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.