Evidence map›Paper›PMID 38399774›Full record

ArticleMicroorganisms2024

Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study.

Chenglin Ye, Zhiqiang Li, Chun Ye, Li Yuan, Kailang Wu, Chengliang Zhu

Abstract read
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
  4. Review
  5. Article
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenglin YeDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Zhiqiang LiDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Chun YeDepartment of General Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Li YuanDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430060, China.
Kailang WuState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Chengliang ZhuDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Funding

Chinese foundation for hepatitis prevention and control-TianQing liver disease research fund subject TGQB20210109Clinical Research Project of Health Industry of Shanghai Municipal Health Commission 202140407Fundamental Research Funds for the Central Universities 2042022kf1215Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai PWZxq2022-08Open Funds of Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province KFJJ-202005, KFJJ-201907Open Research Program of the State Key Laboratory of Virology of China 2021KF002, 2021KF006Special Funds for Innovation in Scientific Research Program of Zhongshan 2020AG024
6 · The paper itself

Abstract

Recent observational studies revealed an association between gut microbiota and aging, but whether gut microbiota are causally associated with the aging process remains unknown. We used a two-sample Mendelian randomization approach to investigate the causal association between gut microbiota and biological age acceleration using the largest available gut microbiota GWAS summary data from the MiBioGen consortium and GWAS data on biological age acceleration. We further conducted sensitivity analysis using MR-PRESSO, MR-Egger regression, Cochran Q test, and reverse MR analysis.

Indexed as

agingbiological aginggut microbiotainstrumental variablesmendelian randomization study

Identifiers

PMID38399774
PMCPMC10891714

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.