Evidence map›Paper›PMID 38400843›Full record

SynthesisVirchows Archiv : an international journal of pathology2024

Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact.

Andrés Coca-Pelaz, Juan P Rodrigo, Abbas Agaimy, Michelle D Williams, Nabil F Saba, Sandra Nuyts, Gregory W Randolph, Fernando López, Vincent Vander Poorten, Luiz P Kowalski and 7 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Multilayered Insights into Poorly Differentiated,Diagnostics (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
  4. NF-κB in Thyroid Cancer: An Update.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Andrés Coca-PelazDepartment of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Av/ Rome S/N. 33011, Oviedo, Asturias, Spain. acocapelaz@yahoo.es.ORCID http://orcid.org/0000-0003-1363-8559
Juan P RodrigoDepartment of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Av/ Rome S/N. 33011, Oviedo, Asturias, Spain.
Abbas AgaimyInstitute of Pathology, Friedrich Alexander University Erlangen-Nürnberg, University Hospital, Erlangen, Germany.
Michelle D WilliamsDepartment of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Nabil F SabaDepartment of Hematology and Medical Oncology, The Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Sandra NuytsLaboratory of Experimental Radiotherapy, Department of Oncology, University of Leuven, Leuven, Belgium.
Gregory W RandolphDivision of Thyroid and Parathyroid Endocrine Surgery, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
Fernando LópezDepartment of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Av/ Rome S/N. 33011, Oviedo, Asturias, Spain.
Vincent Vander PoortenDepartment of Oncology, Section Head and Neck Oncology, KU Leuven, Leuven, Belgium.
Luiz P KowalskiDepartment of Otorhinolaryngology-Head and Neck Surgery, A.C. Camargo Cancer Center, São Paulo, Brazil.
Francisco J CivantosDepartment of Otolaryngology-Head and Neck Surgery, Sylvester Cancer Center, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Mark E ZafereoDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Antti A MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery, Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Oded CohenSamson Assuta Ashdod University Hospital, Affiliated With Ben Gurion University, Beer Sheva, Israel.
Iain J NixonDepartment of Surgery and Otolaryngology, Head and Neck Surgery, Edinburgh University, Edinburgh, Scotland, UK.
Alessandra RinaldoENT Unit, Policlinico Città di Udine, Udine, Italy.ORCID http://orcid.org/0000-0001-7956-6709
Alfio FerlitoCoordinator of the International Head and Neck Scientific Group, Padua, Italy.ORCID http://orcid.org/0000-0002-8247-8002

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poorly differentiated thyroid carcinomas (PDTC) are rare diseases; nevertheless, they account for the majority of deaths from non-anaplastic follicular cell-derived thyroid carcinomas. Establishing the diagnosis and treatment of PDTC is challenging given the low incidence and the lack of standardization of diagnostic criteria. These limitations hamper the ability to compare therapeutic modalities and outcomes between recent and older studies. Recently, the 5th edition of the classification of endocrine tumors has been published, which includes changes in nomenclature and the addition of the disease entity of "differentiated high-grade follicular cell-derived carcinomas". On the other hand, the recently witnessed advances in molecular diagnostics have enriched therapeutic options and improved prognosis for patients. We herein review the various historical variations and evolution in the diagnostic criteria for PDTC. This systematic review attempts to clarify the evolution of the histological and molecular characteristics of this disease, its prognosis, as well as its treatment options.

Indexed as

Thyroid NeoplasmsAdenocarcinoma, FollicularCell DifferentiationHumansPrognosisHigh-grade follicular derived thyroid carcinomaOutcomePoorly differentiated thyroid cancerRadioiodineTreatment

Identifiers

PMID38400843

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.