Evidence map›Paper›PMID 38402172›Full record

ArticleBMC pediatrics2024

Zonulin and copeptin relation to some metabolic markers in school-aged obese children.

Sahar Abd El-Raufe El-Masry, Rehab A Mahmoud, Nayera E Hassan, Manal M Aly, Hanaa Reyad Abdallah, Sherin Hamdy, Safinaz Megahed, Dina Y Elalfy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sahar Abd El-Raufe El-MasryBiological Anthropology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt. masrysa@yahoo.com.ORCID 0000-0002-1416-0633
Rehab A MahmoudFaculty of Post Graduate Childhood Studies, Ain-Shams University, Cairo, Egypt.
Nayera E HassanBiological Anthropology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt.ORCID 0000-0002-3344-0024
Manal M AlyBiological Anthropology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt.ORCID 0000-0002-0819-7018
Hanaa Reyad AbdallahBiological Anthropology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt.ORCID 0000-0002-9057-1290
Sherin HamdyClinical and Chemical Pathology Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.ORCID 0000-0002-9953-3899
Safinaz MegahedBiological Anthropology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt.
Dina Y ElalfyFaculty of Post Graduate Childhood Studies, Ain-Shams University, Cairo, Egypt.ORCID 0000-0002-4453-3998
National Research Centre · EGAin Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUsing Zonulin and Copeptin as potential obesity markers in children, hasn't yet been focused.

aimTo evaluate the association between serum levels of both Zonulin and Copeptin with the obesity markers, and to assess their role as metabolic disturbance predictors in obese children.

methodsA case-control study comprised 111 Egyptian children (45 males and 66 females); aged 6-10 years to avoid the effect of puberty (prepubertal). They were classified according to their body mass index (BMI) percentiles into: 72 obese (BMI ≥ 95th ), and 39 control ones (BMI > 15th - <85th ), based on the Egyptian Growth Charts for children and adolescents. Anthropometric parameters and blood pressure were measured, and body composition analysis, lipid profile, Zonulin, and Copeptin levels were assessed.

resultsThe obese group showed a significantly higher value of Copeptin and a lower value of Zonulin than the control one Also, the obese group showed significant negative correlations between Zonulin and both anthropometric obesity markers and body composition, whereas Copeptin showed significant positive ones. Moreover, significant positive correlations were found between Copeptin and both body weight and fat distribution. Insignificant correlations were observed between both serum Zonulin and Copeptin levels and blood pressure and lipid profile.

conclusionZonulin and Copeptin cannot be used as metabolic disturbance predictors, among Egyptian children, as they were insignificantly correlated with lipid profile or blood pressure.

Indexed as

GlycopeptidesHaptoglobinsPediatric ObesityProtein PrecursorsAdolescentBody Mass IndexCase-Control StudiesChildFemaleHumansLipidsMalecopeptinsGlycopeptidesHaptoglobinsLipidsProtein PrecursorszonulinBody compositionCopeptinEgyptian obese childrenFat distributionMetabolic markersZonulin

Identifiers

PMID38402172
PMCPMC10893639
OpenAlexW4392131572

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.