Evidence map›Paper›PMID 38402364›Full record

GuidelineHepatology international2024

Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update.

Yimin Mao, Shiwu Ma, Chenghai Liu, Xiaoyan Liu, Minghua Su, Dongliang Li, Yiling Li, Gongying Chen, Jun Chen, Jinjun Chen and 12 more

Registry-linked trialOpen access · hybridAbstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Hepatology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06922669 (Efficacy and Safety of Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia), which is not on this map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
19.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06922669 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy and Safety of Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia: A Multicenter Randomized Controlled Trial

TypeinterventionalSponsorGeneral Hospital of Shenyang Military RegionRan2025 to 2027Enrolled232ConditionsDrug Induced Liver InjuryArmsMethylprednisolone, Magnesium isoglycyrrhizinate, Glutathione, Silymarin, Polyene Phosphatidylcholine
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
  2. HBV/HCV coinfection and anti-tuberculosis drug-induced liver injury: from risk assessment and exploration of mechanisms to preventive considerations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  3. Article
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  13. [Gut microbiota-associated metabolites with drug-induced liver injury].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 15 institutions in 1 country.

Yimin MaoDivision of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, NHC Key Laboratory of Digestive Diseases, Shanghai Research Center of Fatty Liver Disease, Shanghai, 200001, China. maoym11968@163.com.ORCID http://orcid.org/0000-0002-2928-3425
Shiwu MaDepartment of Infectious Diseases, The 920th Hospital of Chinese PLA Joint Logistics Support Force, Kunming, 650032, Yunnan, China.
Chenghai LiuInstitute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Xiaoyan LiuDepartment of Pharmacy, Huangpu Branch of the 9th People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.
Minghua SuDepartment of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
Dongliang LiDepartment of Hepatobiliary Medicine, The 900th Hospital of Chinese PLA Joint Logistics Support Force, Fuzhou, 350025, Fujian, China.
Yiling LiDepartment of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Gongying ChenDepartment of Liver Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang, China.
Jun ChenDepartment of Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, 518112, Guangdong, China.
Jinjun ChenHepatology Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Jingmin ZhaoDepartment of Pathology and Hepatology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.
Xiaoyan GuoDepartment of Gastroenterology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Jieting TangDivision of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, NHC Key Laboratory of Digestive Diseases, Shanghai Research Center of Fatty Liver Disease, Shanghai, 200001, China.
Yuzheng ZhugeDepartment of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu, China.
Qing XieDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Wen XieCenter of Liver Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, 100088, China.
Rongtao LaiDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Dachuan CaiDepartment of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China.
Qingxian CaiDepartment of Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, 518112, Guangdong, China.
Yang ZhiDivision of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, NHC Key Laboratory of Digestive Diseases, Shanghai Research Center of Fatty Liver Disease, Shanghai, 200001, China.
Xiaoyun LiDivision of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, NHC Key Laboratory of Digestive Diseases, Shanghai Research Center of Fatty Liver Disease, Shanghai, 200001, China.
Technology Committee on DILI Prevention, Management, Chinese Medical Biotechnology Association; Study Group on Drug-Induced Liver Disease, Chinese Society of Hepatology, Chinese Medical Association
Renji Hospital · CNShenzhen Third People’s Hospital · CNRuijin Hospital · CNAffiliated Hospital of Hangzhou Normal University · CNBeijing Ditan Hospital · CNChinese PLA General Hospital · CNDalian Medical University · CNFirst Hospital of China Medical University · CNGuangxi Medical University · CNNanjing Drum Tower Hospital · CNPeople's Liberation Army 401 Hospital · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNShanghai Jiao Tong University · CNShanghai University of Traditional Chinese Medicine · CNThe 180th Hospital of PLA · CN

Funding

Key Technologies Research and Development Program 2022YFC3502101National Major Science and Technology Projects of China 2017ZX09304016National Natural Science Foundation of China NSFC 81970513National Natural Science Foundation of China NSFC 82270619
6 · The paper itself

Abstract

Drug-induced liver injury (DILI) is an important adverse drug reaction that can lead to acute liver failure or even death in severe cases. Currently, the diagnosis of DILI still follows the strategy of exclusion. Therefore, a detailed history taking and a thorough and careful exclusion of other potential causes of liver injury is the key to correct diagnosis. This guideline was developed based on evidence-based medicine provided by the latest research advances and aims to provide professional guidance to clinicians on how to identify suspected DILI timely and standardize the diagnosis and management in clinical practice. Based on the clinical settings in China, the guideline also specifically focused on DILI in chronic liver disease, drug-induced viral hepatitis reactivation, common causing agents of DILI (herbal and dietary supplements, anti-tuberculosis drugs, and antineoplastic drugs), and signal of DILI in clinical trials and its assessment.

Indexed as

Antineoplastic AgentsChemical and Drug Induced Liver InjuryLiver Failure, AcuteChinaHumansRisk FactorsAntineoplastic AgentsDiagnosisDrugGuidelineHerbal and dietary supplementsLiver injuryManagementPhenotypesPreventionPrognosisTreatment

Identifiers

PMID38402364
OpenAlexW4392146720

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.