Evidence map›Paper›PMID 38403687›Full record

Trial reportOrphanet journal of rare diseases2024

Clinical efficacy of metformin in familial adenomatous polyposis and the effect of intestinal flora.

Linxin Zhou, Linfu Zheng, Binbin Xu, Zhou Ye, Dazhou Li, Wen Wang

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Orphanet journal of rare diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Linxin Zhou *Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, 350025, China.
Linfu Zheng *Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, 350025, China.
Binbin XuFuzong Clinical Medical College of Fujian Medical University, Fuzhou, 350025, China.
Zhou YeFuzong Clinical Medical College of Fujian Medical University, Fuzhou, 350025, China.
Dazhou LiFuzong Clinical Medical College of Fujian Medical University, Fuzhou, 350025, China. LDZ7302999@sina.com.
Wen WangFuzong Clinical Medical College of Fujian Medical University, Fuzhou, 350025, China. wangwenfj@163.com.ORCID 0000-0003-0001-3672
Fujian Medical University · CN

Funding

intra-hospital issues at the 900th Hospital of the Joint Security Force 2020L07Natural Science Foundation of Fujian Province 2023J011358the Foreign Cooperation Project of the Department of Science and Technology of Fujian Province 2022I0033
6 · The paper itself

Abstract

BACKGROUND AND

aimsMetformin has been reported to inhibit the occurrence and development of colorectal cancer (CRC) by mediating changes in intestinal flora. Studies have also indicated that the occurence of familial adenomatous polyposis (FAP) may also be associated with changes in the intestinal flora. Therefore, we investigated the efficacy and safety of metformin in treating FAP and the association with intestinal flora.

resultsCompared with the baseline, the mean number and load of polyps in the areas of nanocarbon labeling and postoperative residuals in the test group were lower than those in the placebo group, while the diversity of intestinal flora species was increased. At the genus level, the relative abundance of g_Ruminococcus in the test group was lower than that at baseline, whereas the relative abundance of g_Lactobacillus was higher. These changes were statistically significant (P < 0.05).

conclusionOne-year metformin therapy for FAP is safe and effective, potentially mediated by modulating the intestinal flora. This study provides new insights and strategies for preventing adenomatous polyp carcinogenesis in FAP and explores possible preventive action.

Indexed as

Adenomatous Polyposis ColiGastrointestinal MicrobiomeDouble-Blind MethodHumansProspective StudiesTreatment OutcomeChemopreventionFamilial adenomatous polyposisIntestinal floraMetformin

Identifiers

PMID38403687
PMCPMC10895836
OpenAlexW4392142628

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.