Evidence map›Paper›PMID 38405702›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Microvascular insulin resistance associates with enhanced muscle glucose disposal in CD36 deficiency.

Cyndya Shibao, Vivek S Peche, Ian M Williams, Dmitri Samovski, Terri A Pietka, Naji N Abumrad, Eric Gamazon, Ira J Goldberg, David Wasserman, Nada A Abumrad

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Cyndya ShibaoDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville TN.
Vivek S PecheDepartment of Medicine, Division of Nutritional Sciences and Obesity Research, Washington University School of Medicine, St. Louis, MO.
Ian M WilliamsDepartment of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville TN.ORCID 0000-0003-2906-8116
Dmitri SamovskiDepartment of Medicine, Division of Nutritional Sciences and Obesity Research, Washington University School of Medicine, St. Louis, MO.
Terri A PietkaDepartment of Medicine, Division of Nutritional Sciences and Obesity Research, Washington University School of Medicine, St. Louis, MO.
Naji N AbumradDepartment of Surgery, Vanderbilt University Medical Center, Nashville TN.
Eric GamazonDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, TN.
Ira J GoldbergDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, New York University Grossman School of Medicine, New York, NY.
David WassermanDepartment of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville TN.
Nada A AbumradDepartment of Medicine, Division of Nutritional Sciences and Obesity Research, Washington University School of Medicine, St. Louis, MO.
Washington University in St. Louis · USVanderbilt University Medical Center · USVanderbilt University · USNew York University · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR002243 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2025 to 2025
$10.7M
Washington University Nutrition Obesity Research CenterP30DK056341 · WASHINGTON UNIVERSITY · 1999 to 2025
$5.7M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · 2022 to 2025
$5.6M
Pathways of Tissue Lipid UptakeR01HL045095 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Nada A. Abumrad, Ira J Goldberg · 1991 to 2024
$2.3M
NCATS NIH HHS UL1 TR002243NHLBI NIH HHS R01 HL045095NHLBI NIH HHS R01 HL157584NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK111175
6 · The paper itself

Abstract

Dysfunction of endothelial insulin delivery to muscle associates with insulin resistance. CD36, a fatty acid transporter and modulator of insulin signaling is abundant in endothelial cells, especially in capillaries. Humans with inherited 50% reduction in CD36 expression have endothelial dysfunction but whether it is associated with insulin resistance is unclear. Using hyperinsulinemic/euglycemic clamps in

Indexed as

African AmericansEndothelial functionmicrovascular circulationnitric oxide

Identifiers

PMID38405702
PMCPMC10889024
OpenAlexW4391916823

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.