Evidence map›Paper›PMID 38407149›Full record

ArticleeLife2024

Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling.

E Nicholas Petersen, Mahmud Arif Pavel, Samuel S Hansen, Manasa Gudheti, Hao Wang, Zixuan Yuan, Keith R Murphy, William Ja, Heather A Ferris, Erik Jorgensen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

E Nicholas PetersenDepartments of Molecular Medicine, The Scripps Research Institute, Scripps, Jupiter, United States.ORCID https://orcid.org/0000-0002-3243-9611
Mahmud Arif PavelDepartments of Molecular Medicine, The Scripps Research Institute, Scripps, Jupiter, United States.
Samuel S HansenDepartments of Molecular Medicine, The Scripps Research Institute, Scripps, Jupiter, United States.
Manasa GudhetiDivision of Endocrinology and Metabolism, Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, United States.
Hao WangDepartments of Molecular Medicine, The Scripps Research Institute, Scripps, Jupiter, United States.
Zixuan YuanDepartments of Molecular Medicine, The Scripps Research Institute, Scripps, Jupiter, United States.ORCID https://orcid.org/0000-0003-0665-5086
Keith R MurphyDepartment of Neuroscience, The Scripps Research Institute, Scripps, Jupiter, United States.
William JaDepartment of Neuroscience, The Scripps Research Institute, Scripps, Jupiter, United States.
Heather A FerrisDivision of Endocrinology and Metabolism, Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, United States.
Erik JorgensenDepartment of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, United States.
Scott B HansenDepartments of Molecular Medicine, The Scripps Research Institute, Scripps, Jupiter, United States.ORCID https://orcid.org/0000-0003-0086-9753
Scripps Research Institute · USUniversity of Virginia · USHoward Hughes Medical Institute · US

Funding

Molecular Mechanism of MechanosensationDP2NS087943 · NINDS · SCRIPPS FLORIDA · PI HANSEN, SCOTT B · 2013 to 2013
$2.8M
The role of lipid raft disruption in the activation of TREK-1 channels by anestheticsR01NS112534 · NINDS · UNIVERSITY OF FLORIDA · PI HANSEN, SCOTT B · 2019 to 2023
$2.2M
Nutritional and Epigenetic Priming of Metabolism and Aging in DrosophilaR01AG045036 · NIA · SCRIPPS FLORIDA · PI JA, WILLIAM W · 2014 to 2018
$2.0M
Regulation of amyloid production by focused ultrasoundR21AG078845 · NIA · UNIVERSITY OF FLORIDA · PI HANSEN, SCOTT B · 2022 to 2022
$515k
NIA NIH HHS R01 AG045036NIA NIH HHS R21 AG078845NIH HHS DP2NS087943-01NIH HHS R01AG045036NIH HHS R01NS112534NINDS NIH HHS DP2 NS087943NINDS NIH HHS R01 NS112534
6 · The paper itself

Abstract

Rapid conversion of force into a biological signal enables living cells to respond to mechanical forces in their environment. The force is believed to initially affect the plasma membrane and then alter the behavior of membrane proteins. Phospholipase D2 (PLD2) is a mechanosensitive enzyme that is regulated by a structured membrane-lipid site comprised of cholesterol and saturated ganglioside (GM1). Here we show stretch activation of TWIK-related K

Indexed as

G(M1) GangliosideSignal TransductionAnimalsCell MembraneCholesterolMammalsMiceSecond Messenger SystemsCholesterolG(M1) GangliosidecholesterolD. melanogasterlipid raftmechanosensationmouseneurosciencePIP2shear thinningTREK

Identifiers

PMID38407149
PMCPMC10942622
OpenAlexW4385358666

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.