Evidence map›Paper›PMID 38408050›Full record

Trial reportPloS one2024

Characterisation of biomarkers of intestinal barrier function in response to a high fat/high carbohydrate meal and corticotropin releasing hormone.

Tamara Mogilevski, Sam Rosella, Anke Nguyen, Jessica Fitzpatrick, Francis Parker, Emma P Halmos, Peter R Gibson

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tamara MogilevskiDepartment of Gastroenterology, Central Clinical School, Monash University and Alfred Health, Melbourne, Australia.ORCID 0000-0002-8954-2978
Sam RosellaDepartment of Gastroenterology, Central Clinical School, Monash University and Alfred Health, Melbourne, Australia.
Anke NguyenDepartment of Gastroenterology, Central Clinical School, Monash University and Alfred Health, Melbourne, Australia.
Jessica FitzpatrickDepartment of Gastroenterology, Central Clinical School, Monash University and Alfred Health, Melbourne, Australia.
Francis ParkerDepartment of Gastroenterology, Central Clinical School, Monash University and Alfred Health, Melbourne, Australia.
Emma P HalmosDepartment of Gastroenterology, Central Clinical School, Monash University and Alfred Health, Melbourne, Australia.ORCID 0000-0002-6063-5118
Peter R GibsonDepartment of Gastroenterology, Central Clinical School, Monash University and Alfred Health, Melbourne, Australia.
Alfred Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVariation of circulating concentrations of putative biomarkers of intestinal barrier function over the day and after acute physiological interventions are poorly documented on humans. This study aimed to examine the stability and pharmacokinetics of changes in plasma concentrations of intestinal Fatty-acid -binding -protein (IFABP), Lipopolysaccharide-binging-protein (LBP), soluble CD14, and Syndecan-1 after acute stress and high fat-high-carbohydrate meal.

methodsIn a single-blinded, cross-over, randomised study, healthy volunteers received on separate days corticotropin-releasing hormone (CRH, 100 μg) or normal saline (as placebo) intravenously in random order, then a HFHC meal. Participants were allowed low caloric food. Markers of intestinal barrier function were measured at set timed intervals from 30 minutes before to 24 hours after interventions.

results10 participants (50% female) completed all three arms of the study. IFABP decreased by median 3.6 (IQR 1.4-10)% from -30 minutes to zero time (p = 0.001) and further reduced by 25 (20-52)% at 24 hours (p = 0.01) on the low caloric diet, but did not change in response to the meal. Syndecan-1, LBP and sCD14 were stable over a 24-hour period and not affected acutely by food intake. LBP levels 2 hours after CRH reduced by 0.61 (-0.95 to 0.05) μg/ml compared with 0.16 (-0.3 to 0.5) μg/ml post placebo injection (p = 0.05), but other markers did not change.

conclusionConcentrations of IFABP, but not other markers, are unstable over 24 hours and should be measured fasting. A HFHC meal does not change intestinal permeability. Transient reduction of LPB after CRH confirms acute barrier dysfunction during stress.

Indexed as

Corticotropin-Releasing HormoneSyndecan-1BiomarkersFemaleHumansIntestinal Barrier FunctionLipopolysaccharidesMaleBiomarkersCorticotropin-Releasing HormoneLipopolysaccharidesSyndecan-1

Identifiers

PMID38408050
PMCPMC10896497
OpenAlexW4392183109

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.