Evidence map›Paper›PMID 38408634›Full record

ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2024

Antimicrobial cetylpyridinium chloride causes functional inhibition of mitochondria as potently as canonical mitotoxicants, nanostructural disruption of mitochondria, and mitochondrial Ca

Sasha R Weller, John E Burnell, Brandon M Aho, Bright Obeng, Emily L Ledue, Juyoung K Shim, Samuel T Hess, Julie A Gosse

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sasha R WellerDepartment of Molecular and Biomedical Sciences, 5735 Hitchner, University of Maine, Orono, ME, 04469, USA.
John E BurnellDepartment of Molecular and Biomedical Sciences, 5735 Hitchner, University of Maine, Orono, ME, 04469, USA.
Brandon M AhoDepartment of Physics and Astronomy, 5709 Bennett Hall, University of Maine, Orono, ME, 04469, USA.
Bright ObengDepartment of Molecular and Biomedical Sciences, 5735 Hitchner, University of Maine, Orono, ME, 04469, USA.
Emily L LedueDepartment of Molecular and Biomedical Sciences, 5735 Hitchner, University of Maine, Orono, ME, 04469, USA.
Juyoung K ShimDepartment of Biology, Jewett Hall, University of Maine at Augusta, Augusta, ME, 04330, USA.
Samuel T HessDepartment of Physics and Astronomy, 5709 Bennett Hall, University of Maine, Orono, ME, 04469, USA. Electronic address: Samuel.hess@maine.edu.
Julie A GosseDepartment of Molecular and Biomedical Sciences, 5735 Hitchner, University of Maine, Orono, ME, 04469, USA. Electronic address: Julie.gosse@maine.edu.
University of Maine · USUniversity of Maine at Augusta · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Mechanism of Interaction between Influenza Hemagglutinin and Host Cell PhosphoinositidesR15GM139070 · NIGMS · UNIVERSITY OF MAINE ORONO · PI HESS, SAMUEL T · 2020 to 2020
$428k
NIGMS NIH HHS P20 GM103423NIGMS NIH HHS R15 GM139070
6 · The paper itself

Abstract

People are exposed to high concentrations of antibacterial agent cetylpyridinium chloride (CPC) via food and personal care products, despite little published information regarding CPC effects on eukaryotes. Here, we show that low-micromolar CPC exposure, which does not cause cell death, inhibits mitochondrial ATP production in primary human keratinocytes, mouse NIH-3T3 fibroblasts, and rat RBL-2H3 immune mast cells. ATP inhibition via CPC (EC

Indexed as

Anti-Infective AgentsAnti-Infective Agents, LocalAdenosine TriphosphateAnimalsCetylpyridiniumHumansMiceMitochondriaRatsRodentiaAdenosine TriphosphateAnti-Infective AgentsAnti-Infective Agents, LocalCetylpyridiniumAntibacterial agentATPCetylpyridinium chlorideFluorescence photoactivation localization microscopy (FPALM)KeratinocyteMast cellMitochondriaMitochondrial calciumMitotoxicityOxygen consumption rateQuaternary ammonium compoundSuper-resolution microscopy

Identifiers

PMID38408634
PMCPMC11060648
OpenAlexW4392128319

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.