Evidence map›Paper›PMID 38409562›Full record

ArticleEuropean radiology experimental2024

Choroid plexus volume in multiple sclerosis can be estimated on structural MRI avoiding contrast injection.

Valentina Visani, Francesca B Pizzini, Valerio Natale, Agnese Tamanti, Mariagiulia Anglani, Alessandra Bertoldo, Massimiliano Calabrese, Marco Castellaro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European radiology experimental, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Choroid Plexus Volume in Pediatric-Onset Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Valentina VisaniDepartment of Information Engineering, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-3467-7920
Francesca B PizziniDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-6285-0989
Valerio NataleDepartment of Diagnostic and Public Health, University of Verona, Verona, Italy.
Agnese TamantiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0001-9972-4348
Mariagiulia AnglaniNeuroradiology Unit, University Hospital of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-3989-4553
Alessandra BertoldoDepartment of Information Engineering, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-6262-6354
Massimiliano CalabreseDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-3362-7403
Marco CastellaroDepartment of Information Engineering, University of Padova, Padova, Italy. marco.castellaro@unipd.it.ORCID http://orcid.org/0000-0002-1203-2670
University of Padua · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We compared choroid plexus (ChP) manual segmentation on non-contrast-enhanced (non-CE) sequences and reference standard CE T1- weighted (T1w) sequences in 61 multiple sclerosis patients prospectively included. ChP was separately segmented on T1w, T2-weighted (T2w) fluid-attenuated inversion-recovery (FLAIR), and CE-T1w sequences. Inter-rater variability assessed on 10 subjects showed high reproducibility between sequences measured by intraclass correlation coefficient (T1w 0.93, FLAIR 0.93, CE-T1w 0.99). CE-T1w showed higher signal-to-noise ratio and contrast-to-noise ratio (CE-T1w 23.77 and 18.49, T1w 13.73 and 7.44, FLAIR 13.09 and 10.77, respectively). Manual segmentation of ChP resulted 3.073 ± 0.563 mL (mean ± standard deviation) on T1w, 3.787 ± 0.679 mL on FLAIR, and 2.984 ± 0.506 mL on CE-T1w images, with an error of 28.02 ± 19.02% for FLAIR and 3.52 ± 12.61% for T1w. FLAIR overestimated ChP volume compared to CE-T1w (p < 0.001). The Dice similarity coefficient of CE-T1w versus T1w and FLAIR was 0.67 ± 0.05 and 0.68 ± 0.05, respectively. Spatial error distribution per slice was calculated after nonlinear coregistration to the standard MNI152 space and showed a heterogeneous profile along the ChP especially near the fornix and the hippocampus. Quantitative analyses suggest T1w as a surrogate of CE-T1w to estimate ChP volume.Relevance statement To estimate the ChP volume, CE-T1w can be replaced by non-CE T1w sequences because the error is acceptable, while FLAIR overestimates the ChP volume. This encourages the development of automatic tools for ChP segmentation, also improving the understanding of the role of the ChP volume in multiple sclerosis, promoting longitudinal studies.Key points • CE-T1w sequences are considered the reference standard for ChP manual segmentation.• FLAIR sequences showed a higher CNR than T1w sequences but overestimated the ChP volume.• Non-CE T1w sequences can be a surrogate of CE-T1w sequences for manual segmentation of ChP.

Indexed as

Multiple SclerosisChoroid PlexusHumansMagnetic Resonance ImagingReproducibility of ResultsSignal-To-Noise RatioChoroid plexusGadolinium-based contrast mediaImage segmentationMagnetic resonance imagingMultiple sclerosis

Identifiers

PMID38409562
PMCPMC10897123
OpenAlexW4392165892

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.