Evidence map›Paper›PMID 38410080›Full record

ArticleObesity (Silver Spring, Md.)2024

Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity.

Aaron L Slusher, Jessica Nouws, Fuyuze Tokoglu, Alla Vash-Margita, Marcy D Matthews, Mark Fitch, Mahalakshmi Shankaran, Marc K Hellerstein, Sonia Caprio

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Aaron L SlusherDepartment of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-2082-4827
Jessica NouwsSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Fuyuze TokogluDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Alla Vash-MargitaDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA.
Marcy D MatthewsDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA.
Mark FitchDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA.
Mahalakshmi ShankaranDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA.
Marc K HellersteinDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA.
Sonia CaprioDepartment of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.
Yale University · USUniversity of California, Berkeley · US

Funding

METABOLIC PREDICTORS AND MARKERS OF CHILDHOOD OBESITYR01HD028016 · NICHD · YALE UNIVERSITY · PI CAPRIO, SONIA · 1991 to 2024
$8.9M
Pathogenesis of youth onset pre-diabetes and Type 2 diabetesR01DK111038 · NIDDK · YALE UNIVERSITY · PI CAPRIO, SONIA · 2016 to 2025
$7.0M
Study to Investigate the Pathophysiology of Type 2 Diabetes in YouthR01HD040787 · NICHD · YALE UNIVERSITY · PI CAPRIO, SONIA · 2000 to 2014
$5.6M
PATHOPHYSIOLOGY OF METABOLIC DEFECTS OF JUVENILE OBESITYK24HD001464 · NICHD · YALE UNIVERSITY · PI CAPRIO, SONIA · 2001 to 2010
$1.4M
NICHD NIH HHS K24 HD001464NICHD NIH HHS R01 HD028016NICHD NIH HHS R01 HD040787NIDDK NIH HHS R01 DK111038
6 · The paper itself

Abstract

objectiveThe objective of this study was to examine the hypothesis that abdominal and gluteal adipocyte turnover, lipid dynamics, and fibrogenesis are dysregulated among insulin-resistant (IR) compared with insulin-sensitive (IS) adolescents with obesity.

methodsSeven IS and seven IR adolescents with obesity participated in a 3-h oral glucose tolerance test and a multi-section magnetic resonance imaging scan of the abdominal region to examine body fat distribution patterns and liver fat content. An 8-week 70% deuterated water (

resultsAbdominal and gluteal subcutaneous adipose tissue (SAT) turnover rates of lipid components were similar among IS and IR adolescents with obesity. However, the insoluble collagen (type I, subunit α2) isoform measured from abdominal, but not gluteal, SAT was elevated in IR compared with IS individuals. In addition, abdominal insoluble collagen Iα2 was associated with ratios of visceral-to-total (visceral adipose tissue + SAT) abdominal fat and whole-body and adipose tissue insulin signaling, and it trended toward a positive association with liver fat content.

conclusionsAltered extracellular matrix dynamics, but not expandability, potentially decreases abdominal SAT lipid storage capacity, contributing to the pathophysiological pathways linking adipose tissue and whole-body IR with altered ectopic storage of lipids within the liver among IR adolescents with obesity.

Indexed as

Insulin ResistancePediatric ObesityAdolescentChildCollagenExtracellular MatrixHumansInsulinIntra-Abdominal FatLipidsSubcutaneous FatCollagenInsulinLipids

Identifiers

PMID38410080
PMCPMC11034857
OpenAlexW4392197575

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.