Evidence map›Paper›PMID 38413743›Full record

ArticleScientific reports2024

Endogenous chondroitin extends the lifespan and healthspan in C. elegans.

Yukimasa Shibata, Yuri Tanaka, Hiroyuki Sasakura, Yuki Morioka, Toshihiro Sassa, Shion Fujii, Kaito Mitsuzumi, Masashi Ikeno, Yukihiko Kubota, Kenji Kimura and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Yukimasa ShibataDepartment of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan. yukshibata@kwansei.ac.jp.
Yuri TanakaDepartment of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan.
Hiroyuki SasakuraDepartment of Medical Cell Biology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan.
Yuki MoriokaDepartment of Medical Cell Biology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan.
Toshihiro SassaRIKEN Center for Developmental Biology, Kobe, Hyogo, Japan.
Shion FujiiDepartment of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan.
Kaito MitsuzumiDepartment of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan.
Masashi IkenoDepartment of Medical Cell Biology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan.
Yukihiko KubotaDepartment of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan.
Kenji KimuraDepartment of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan.
Hidenao ToyodaLaboratory of Bio-Analytical Chemistry, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan.
Kosei TakeuchiDepartment of Medical Cell Biology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan.
Kiyoji NishiwakiDepartment of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan.
Kwansei Gakuin University · JPAichi Medical University · JPRitsumeikan University · JPRIKEN Center for Computational Science · JP

Funding

JP Ministry of Education, Culture, Sports, Science and Technology 22K20658
6 · The paper itself

Abstract

Chondroitin, a class of glycosaminoglycan polysaccharides, is found as proteoglycans in the extracellular matrix, plays a crucial role in tissue morphogenesis during development and axonal regeneration. Ingestion of chondroitin prolongs the lifespan of C. elegans. However, the roles of endogenous chondroitin in regulating lifespan and healthspan mostly remain to be investigated. Here, we demonstrate that a gain-of-function mutation in MIG-22, the chondroitin polymerizing factor (ChPF), results in elevated chondroitin levels and a significant extension of both the lifespan and healthspan in C. elegans. Importantly, the remarkable longevity observed in mig-22(gf) mutants is dependent on SQV-5/chondroitin synthase (ChSy), highlighting the pivotal role of chondroitin in controlling both lifespan and healthspan. Additionally, the mig-22(gf) mutation effectively suppresses the reduced healthspan associated with the loss of MIG-17/ADAMTS metalloprotease, a crucial for factor in basement membrane (BM) remodeling. Our findings suggest that chondroitin functions in the control of healthspan downstream of MIG-17, while regulating lifespan through a pathway independent of MIG-17.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsChondroitinDisintegrinsGlycosaminoglycansLongevityMetalloendopeptidasesCaenorhabditis elegans ProteinsChondroitinDisintegrinsGlycosaminoglycansMetalloendopeptidasesMIG-17 protein, C elegansADAMTS proteaseAgingBasement membraneChondroitin

Identifiers

PMID38413743
PMCPMC10899230
OpenAlexW4392189092

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.