Evidence mapPaperPMID 38414479Full record

ArticleArchives of medical science : AMS2024

Recommendations of the Experts of the Polish Cardiac Society (PCS) and the Polish Lipid Association (PoLA) on the diagnosis and management of elevated lipoprotein(a) levels.

Bożena Sosnowska, Janina Stepinska, Przemyslaw Mitkowski, Agata Bielecka-Dabrowa, Beata Bobrowska, Jan Budzianowski, Pawel Burchardt, Krzysztof Chlebus, Piotr Dobrowolski, Mariusz Gasior and 11 more

Abstract read
In one paragraph

Article in Archives of medical science : AMS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Bożena SosnowskaDepartment of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland.
Janina StepinskaNational Institute of Cardiology, Warsaw, Poland.
Przemyslaw Mitkowski1 Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
Agata Bielecka-DabrowaDepartment of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland.
Beata BobrowskaDepartment of Clinical Cardiology and Cardiovascular Interventions, University Hospital in Krakow, Krakow, Poland.
Jan BudzianowskiDepartment of Interventional Cardiology and Cardiac Surgery, University of Zielona Gora, Collegium Medicum, Zielona Gora, Poland.
Pawel BurchardtDepartment of Cardiology, J. Strus Hospital, Poznan, Poland.
Krzysztof ChlebusNational Center for Familial Hypercholesterolemia, 1 Chair and Department of Cardiology, Medical University of Gdansk, Gdansk, Poland.
Piotr DobrowolskiDepartment of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, National Institute of Cardiology, Warsaw, Poland.
Mariusz Gasior3 Department of Cardiology, Silesian Centre for Heart Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Zabrze, Poland.
Piotr JankowskiDepartment of Internal Medicine and Geriatric Cardiology, Medical Centre for Postgraduate Education, Warsaw, Poland.
Jacek KubicaDepartment of Cardiology and Internal Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Agnieszka MickiewiczLipoprotein Apheresis Laboratory, 1 Department of Cardiology, Medical University of Gdansk, Gdansk, Poland.
Malgorzata MysliwiecDepartment of Paediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Gdansk, Poland.
Tadeusz OsadnikDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Aleksander PrejbiszDepartment of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, National Institute of Cardiology, Warsaw, Poland.
Renata Rajtar-SalwaDepartment of Clinical Cardiology and Cardiovascular Interventions, University Hospital in Krakow, Krakow, Poland.
Kristian Wita1 Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Adam WitkowskiDepartment of Interventional Cardiology and Angiology, National Institute of Cardiology, Warsaw, Poland.
Robert GilDepartment of Cardiology, National Medical Institute of the Ministry of Internal Affairs and Administration, Warsaw, Poland.
Maciej BanachDepartment of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoprotein(a) [Lp(a)] is made up of a low-density lipoprotein (LDL) particle and a specific apolipoprotein(a). The blood concentration of Lp(a) is approximately 90% genetically determined, and the main genetic factor determining Lp(a) levels is the size of the apo(a) isoform, which is determined by the number of KIV2 domain repeats. The size of the apo(a) isoform is inversely proportional to the blood concentration of Lp(a). Lp(a) is a strong and independent cardiovascular risk factor. Elevated Lp(a) levels ≥ 50 mg/dl (≥ 125 nmol/l) are estimated to occur in more than 1.5 billion people worldwide. However, determination of Lp(a) levels is performed far too rarely, including Poland, where, in fact, it is only since the 2021 guidelines of the Polish Lipid Association (PoLA) and five other scientific societies that Lp(a) measurements have begun to be performed. Determination of Lp(a) concentrations is not easy due to, among other things, the different sizes of the apo(a) isoforms; however, the currently available certified tests make it possible to distinguish between people with low and high cardiovascular risk with a high degree of precision. In 2022, the first guidelines for the management of patients with elevated lipoprotein(a) levels were published by the European Atherosclerosis Society (EAS) and the American Heart Association (AHA). The first Polish guidelines are the result of the work of experts from the two scientific societies and their aim is to provide clear, practical recommendations for the determination and management of elevated Lp(a) levels.

Indexed as

cardiovascular diseasecardiovascular risklipoprotein(a)managementrecommendations

Identifiers

PMID38414479
PMCPMC10895977

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.