Evidence map›Paper›PMID 38414796›Full record

ArticleRegenerative biomaterials2024

A strategy for mechanically integrating robust hydrogel-tissue hybrid to promote the anti-calcification and endothelialization of bioprosthetic heart valve.

Haoshuang Wu, Nuoya Chen, Tiantian Zheng, Li Li, Mengyue Hu, Yumei Qin, Gaoyang Guo, Li Yang, Yunbing Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haoshuang WuNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Nuoya ChenNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Tiantian ZhengNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Li LiInstitute of Clinical Pathology, West China Hospital of Sichuan University, Chengdu 610041, China.
Mengyue HuCollege of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
Yumei QinNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Gaoyang GuoNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Li YangNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Yunbing WangNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioprosthetic heart valve (BHV) replacement has been the predominant treatment for severe heart valve diseases over decades. Most clinically available BHVs are crosslinked by glutaraldehyde (GLUT), while the high toxicity of residual GLUT could initiate calcification, severe thrombosis, and delayed endothelialization. Here, we construed a mechanically integrating robust hydrogel-tissue hybrid to improve the performance of BHVs. In particular, recombinant humanized collagen type III (rhCOLIII), which was precisely customized with anti-coagulant and pro-endothelialization bioactivity, was first incorporated into the polyvinyl alcohol (PVA)-based hydrogel via hydrogen bond interactions. Then, tannic acid was introduced to enhance the mechanical performance of PVA-based hydrogel and interfacial bonding between the hydrogel layer and bio-derived tissue due to the strong affinity for a wide range of substrates.

Indexed as

anti-calcificationanti-coagulationbioprosthetic heart valvesendothelializationrecombinant humanized collagen type III

Identifiers

PMID38414796
PMCPMC10898858

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.