Evidence map›Paper›PMID 38414852›Full record

ArticleiScience2024

Myoglobin modulates the Hippo pathway to promote cardiomyocyte differentiation.

Krithika Rao, Elizabeth Rochon, Anuradha Singh, Rajaganapathi Jagannathan, Zishan Peng, Haris Mansoor, Bing Wang, Mousumi Moulik, Manling Zhang, Anita Saraf and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Krithika RaoHeart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Elizabeth RochonHeart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Anuradha SinghHeart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Rajaganapathi JagannathanHeart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Zishan PengDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Haris MansoorHeart and Vascular Institute Division of Cardiology, Department of Medicine and Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Bing WangMolecular Therapy Lab, Stem Cell Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Mousumi MoulikHeart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Manling ZhangHeart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Anita SarafHeart and Vascular Institute Division of Cardiology, Department of Medicine and Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Paola CortiHeart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Sruti ShivaHeart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
University of Pittsburgh · USUniversity of Pittsburgh Medical Center · US

Funding

Translational Pulmonary Vascular BiologyT32HL110849 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sruti Shiva · 2012 to 2026
$5.0M
The relationship between blood based bioenergetics and muscle function, mobility, and agingR01AG072734 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANTHONY J MOLINA, Sruti Shiva · 2022 to 2026
$3.1M
Airway epithelial cytoglobin regulates nitric oxide synthase and development of primary ciliary dyskinesia and situs inversusR01HL168775 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Paola Corti, Mark T Gladwin · 2024 to 2026
$2.1M
Tead1 and Cardiac AdaptationR01HL147946 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOULIK, MOUSUMI · 2019 to 2023
$1.9M
Molecular and Functional Evaluation of NOTCH1 Deficient iPSC Derived Cardiomyocytes in Hypoplastic Left Heart SyndromeK08HL161440 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Anita Saraf · 2022 to 2026
$806k
The Role of GCN5L1 Mediated Mitochondria to Nucleus Retrograde Cardiac Metabolism Reprogramming in Exercise and Heart FailureK08HL157616 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHANG, MANLING · 2021 to 2025
$802k
NHLBI NIH HHS K08 HL157616NHLBI NIH HHS K08 HL161440NHLBI NIH HHS R01 HL147946NHLBI NIH HHS R01 HL168775NHLBI NIH HHS T32 HL110849NIA NIH HHS R01 AG072734
6 · The paper itself

Abstract

The endogenous mechanisms that propagate cardiomyocyte differentiation and prevent de-differentiation remain unclear. While the expression of the heme protein myoglobin increases by over 50% during cardiomyocyte differentiation, a role for myoglobin in regulating cardiomyocyte differentiation has not been tested. Here, we show that deletion of myoglobin in cardiomyocyte models decreases the gene expression of differentiation markers and stimulates cellular proliferation, consistent with cardiomyocyte de-differentiation. Mechanistically, the heme prosthetic group of myoglobin catalyzes the oxidation of the Hippo pathway kinase LATS1, resulting in phosphorylation and inactivation of yes-associated protein (YAP).

Indexed as

BiochemistryBiological sciencesCell biologyNatural sciencesSpecialized functions of cells

Identifiers

PMID38414852
PMCPMC10897895
OpenAlexW4391578317

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.